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LRP-6

LRP-6 Overview

English Name	Low-density lipoprotein receptor-related protein 6	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	LDL Receptor Related Protein 6，LRP6
Highest Development Stage	Preclinical

English Name	Low-density lipoprotein receptor-related protein 6
Target Synonym	LDL Receptor Related Protein 6，LRP6
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

LRP-6 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (1)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
LR6-H5253	Human	HEK293	Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag
LR6-H82E7	Human	HEK293	Biotinylated Human LRP-6 (20-630) Protein, His,Avitag™

Total: 2

LRP-6 Background

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.