MAdCAM-1 Informations sur la molécule
Molecule Name
Mucosal addressin cell adhesion molecule-1
Alias de la molécule
MAdCAM-1,MAdCAM1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1
Drug Development Progress
Nombre de médicaments cliniques4
Nombre de médicaments commercialisés1
Phase de R&D la plus avancéeApproved
Alias de la cible
Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
Contexte de la molécule
The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.
MAdCAM-1 Liste de produits
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Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Ontamalimab | SHP-647; PF-00547659; PF-547659 | Phase 3 Clinical | Pfizer Inc | Colitis, Ulcerative; Crohn Disease; Fatty Liver; Ileitis | Details |
| Vedolizumab biosimilar (Polpharma Biologics) | PB-016 | Phase 3 Clinical | Polpharma Biologics Sa | Colitis, Ulcerative; Crohn Disease; Pouchitis | Details |
| Vedolizumab Biosimilar (Intas Pharmaceuticals) | INTP-53; INTP53 | Phase 3 Clinical | Intas Pharmaceuticals Ltd | Colitis, Ulcerative | Details |
| Vedolizumab biosimilar (Alvotech) | AVT-16; AVT16 | Phase 1 Clinical | Alvotech Swiss Ag | Colitis, Ulcerative; Immune System Diseases | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Vedolizumab | MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02 | Approved | Millennium Pharmaceuticals Inc | Entyvio, Entyvio Pen, Kynteles, 安吉优 | United States | Colitis, Ulcerative; Crohn Disease | Takeda Pharmaceuticals USA Inc | 2014-05-20 | Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms | Details |