MAdCAM-1

MAdCAM-1 Informations sur la molécule

Nom anglais	Mucosal addressin cell adhesion molecule-1	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	4	Alias de la cible	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
Phase de R&D la plus avancée	Approved

Nom anglais	Mucosal addressin cell adhesion molecule-1
Alias de la cible	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	4
Phase de R&D la plus avancée	Approved

MAdCAM-1 Liste de produits

Attribut
Protein (7)Cell (1)
Bibliothèque de produits
En ligne (8)
Espèces
Human (4)Cynomolgus (2)Mouse (2)
Étiquette
Fc Tag (1)Fc Tag & Avi Tag (1)His Tag (3)His Tag & Avi Tag (2)- (1)
Marqueur
Unconjugated (4)Biotin-labeled (3)- (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT MAM-H5253	Human	HEK293	Human MAdCAM-1 Protein, Fc Tag, low endotoxin (MALS verified)	Ajouter au panier
HOT MAM-H52H4	Human	HEK293	Human MAdCAM-1 Protein, His Tag (MALS & SPR verified)	Ajouter au panier
HOT MAM-H8251	Human	HEK293	Biotinylated Human MAdCAM-1 Protein, Fc,Avitag™ (MALS verified)	Ajouter au panier
CCHO-ATP241	Human	CHO	CHO/Human MAdCAM-1 Stable Cell Line	Ajouter au panier
MAM-M52H3	Mouse	HEK293	Mouse MAdCAM-1 Protein, His Tag, low endotoxin (MALS & SPR verified)	Ajouter au panier
MAM-M82E3	Mouse	HEK293	Biotinylated Mouse MAdCAM-1 Protein, His,Avitag™ (MALS verified)	Ajouter au panier
MAM-C52H3	Cynomolgus	HEK293	Cynomolgus MAdCAM-1 Protein, His Tag, low endotoxin	Ajouter au panier
MAM-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus MAdCAM-1 Protein, His,Avitag™ (MALS verified)	Ajouter au panier

Quantité totale8

MAdCAM-1Contexte de la molécule

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

MAdCAM-1Alias de la molécule

MAdCAM-1,MAdCAM1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Ontamalimab	SHP-647; PF-00547659; PF-547659	Phase 3 Clinical	Pfizer Inc	Colitis, Ulcerative; Crohn Disease; Fatty Liver; Ileitis	Details
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	Details
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	Details
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	Details