MCAM

MCAM Informations sur la molécule

Nom anglais	Melanoma cell adhesion molecule	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2	Alias de la cible	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Melanoma cell adhesion molecule
Alias de la cible	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	2
Phase de R&D la plus avancée	Phase 2 Clinical

MCAM Liste de produits

Attribut
Protein (3)Cell (1)
Bibliothèque de produits
En ligne (4)
Espèces
Human (3)Mouse (1)
Étiquette
His Tag (2)- (1)His Tag & Avi Tag (1)
Marqueur
Unconjugated (2)- (1)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
CD6-H5229	Human	HEK293	Human MCAM / CD146 Protein, His Tag	Ajouter au panier
CHEK-ATP195	Human	HEK293	HEK293/Human MCAM Stable Cell Line	Ajouter au panier
MCM-H82E3	Human	HEK293	Biotinylated Human MCAM / CD146 Protein, His,Avitag™ (MALS verified)	Ajouter au panier
MCM-M52H3	Mouse	HEK293	Mouse MCAM / CD146 Protein, His Tag	Ajouter au panier

Quantité totale4

MCAMContexte de la molécule

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAMAlias de la molécule

MCAM,CD146,MUC18

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
CD146 targeting CAR-T cell therapy (Essen Biotech)		Phase 2 Clinical	Essen Biotech	Carcinoma, Ovarian Epithelial; Osteosarcoma; Ovarian Neoplasms; Sarcoma; Sarcoma, Ewing; Sarcoma, Kaposi; Sarcoma, Synovial	Details
AMT-253(Multitude)	AMT-253; AMT-253 ADC	Phase 2 Clinical	Multitude Therapeutics Inc	Melanoma; Solid tumours	Details