MICA

MICA Informations sur la molécule

Nom anglais	MHC class I polypeptide-related sequence A	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	4	Alias de la cible
Phase de R&D la plus avancée	Phase 1 Clinical

Nom anglais	MHC class I polypeptide-related sequence A
Alias de la cible
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	4
Phase de R&D la plus avancée	Phase 1 Clinical

MICA Liste de produits

Attribut
Protein (10)
Bibliothèque de produits
En ligne (10)
Espèces
Human (9)Cynomolgus (1)
Étiquette
His Tag (3)Fc Tag (2)His Tag & Avi Tag (2)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)Human IgG4 Fc Tag (1)
Marqueur
Unconjugated (7)Biotin-labeled (3)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT MIA-H5221	Human	HEK293	Human MICA Protein, His Tag, low endotoxin (MALS verified)	Ajouter au panier
HOT MIA-H5253	Human	HEK293	Human MICA Protein, Fc Tag	Ajouter au panier
HOT MIA-H52H7	Human	HEK293	Human MICA (24-202) Protein, His Tag (MALS verified)	Ajouter au panier
HOT MIA-H82E4	Human	HEK293	Biotinylated Human MICA (201-309) Protein, His,Avitag™ (MALS verified)	Ajouter au panier
HOT MIA-H82E6	Human	HEK293	Biotinylated Human MICA Protein, His,Avitag™ (MALS verified)	Ajouter au panier
MIA-H5254	Human	HEK293	Human MICA (24-309) Protein, Fc Tag (MALS verified)	Ajouter au panier
MIA-H5255	Human	HEK293	Human MICA (24-202) Protein, Mouse IgG2a Fc Tag (MALS verified)	Ajouter au panier
MIA-H5259	Human	HEK293	Human MICA Protein, IgG4 Fc Tag	Ajouter au panier
MIA-H82F6	Human	HEK293	Biotinylated Human MICA Protein, Fc,Avitag™ (MALS verified)	Ajouter au panier
MIA-C52H5	Cynomolgus	HEK293	Cynomolgus MICA Protein, His Tag (HPLC verified)	Ajouter au panier

Quantité totale10

MICAContexte de la molécule

MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Isuventatug	CLN-619	Phase 1 Clinical	Cullinan MICA Corp	Carcinoma, Non-Small-Cell Lung; Multiple Myeloma; Solid tumours	Details
FT-536	FT-536	Phase 1 Clinical	Fate Therapeutics Inc	Abdominal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Ovarian Neoplasms; Solid tumours	Details
FT-836	FT-836; FT836	Phase 1 Clinical	Fate Therapeutics Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck	Details
DM-919	DM-919; DM919	Phase 1 Clinical	D2M Biotherapeutics Inc	Neoplasms; Solid tumours	Details