MIF

MIF Informations sur la molécule

Nom anglais	Macrophage migration inhibitory factor	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	3	Alias de la cible	EC:5.3.2.1，GIF，EC 5.3.3.12，EC 5.3.2.1，Macrophage Migration-Inhibitory Factors，Epididymis Secretory Sperm Binding Protein，EC:5.3.3.12，Phenylpyruvate Tautomerase，L-Dopachrome Tautomerase，MMIF，Glycosylation-inhibiting factor，L-dopachrome isomerase，MIF，Macrophage Migration Inhibitory Factor，Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor)，GLIF
Phase de R&D la plus avancée	Approved

Nom anglais	Macrophage migration inhibitory factor
Alias de la cible	EC:5.3.2.1，GIF，EC 5.3.3.12，EC 5.3.2.1，Macrophage Migration-Inhibitory Factors，Epididymis Secretory Sperm Binding Protein，EC:5.3.3.12，Phenylpyruvate Tautomerase，L-Dopachrome Tautomerase，MMIF，Glycosylation-inhibiting factor，L-dopachrome isomerase，MIF，Macrophage Migration Inhibitory Factor，Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor)，GLIF
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Approved

MIF Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag & Avi Tag (1)
Marqueur
Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
MIF-H82E7	Human	HEK293	Biotinylated Human MIF Protein, His,Avitag™				Ajouter au panier

Quantité totale1

MIFContexte de la molécule

Macrophage migration inhibitory factor(MIF) is also known as Glycosylation-inhibiting factor(GIF), L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase. Interacts with CXCR2 extracellular domain, CD74 extracellular domain, COPS5 and BNIPL. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

MIFAlias de la molécule

MIF,GLIF,MMIF,GIF

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
IPG-1094	IPG-1094; IPG-001	Phase 2 Clinical	Nanjing Immunophage Biotech Co Ltd	Brain metastases; Brain Neoplasms; Hematologic Neoplasms; Lupus Nephritis; Multiple Myeloma; Multiple Sclerosis; Psoriasis; Solid tumours	Details
TRP2-electroporated autologous dendritic cell therapy (Memorial Sloan-Kettering)		Phase 1 Clinical	Memorial Sloan Kettering Cancer Center	Melanoma	Details
STP-1	STP-1; STP1	Phase 1 Clinical	Stalicla Sa	Autism Spectrum Disorder	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Ibudilast	KC-404; AV-411; MN-166	Approved	Kyorin Pharmaceutical Co Ltd	Ketas, Pinatos, Eyevinal	Japan	Asthma; Multiple Sclerosis; Neuralgia	Kyorin Pharmaceutical Co Ltd		Alcoholism; Amyotrophic Lateral Sclerosis; Asthma; Diabetic Neuropathies; Headache Disorders, Secondary; HIV Infections; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Neuralgia; Opioid-Related Disorders; Pneumonia, Viral; Substance-Related Disorders	Details

Avis sur les produits

S***n2023-04-28
0Mettre un like
Biotinylated Human MIF Protein, His,Avitag™
This product was used for characterization of a novel therapeutic testing kinetics and affinity on SPR with a Cytiva BiotinCAPture kit. It worked phenomenally with both the novel approach and a positive control. Additionally, it was used with a Streptavidin coated ELISA plate (also from Acro), results were phenomenal with that approach as well. Overall, this product has been well received by our team and we have already ordered more to continue testing.