MMP-2

MMP-2 Informations sur la molécule

Nom anglais	Matrix metalloproteinase-2	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	EC:3.4.24.24，Matrix Metallopeptidase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，MMP-2，MMP2，Matrix metalloproteinase-2，72 kDa gelatinase，Matrix Metallopeptidase 2，CLG4A，TBE-1，Matrix Metalloproteinase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，Matrix Metalloproteinase 2，Matrix Metalloproteinase-II，72 KDa Type IV Collagenase，Collagenase Type IV-A，Neutrophil Gelatinase，Gelatinase A，EC 3.4.24.24，MMP-II，MONA，CLG4，EC 3.4.24
Phase de R&D la plus avancée	Phase 1 Clinical

Nom anglais	Matrix metalloproteinase-2
Alias de la cible	EC:3.4.24.24，Matrix Metallopeptidase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，MMP-2，MMP2，Matrix metalloproteinase-2，72 kDa gelatinase，Matrix Metallopeptidase 2，CLG4A，TBE-1，Matrix Metalloproteinase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，Matrix Metalloproteinase 2，Matrix Metalloproteinase-II，72 KDa Type IV Collagenase，Collagenase Type IV-A，Neutrophil Gelatinase，Gelatinase A，EC 3.4.24.24，MMP-II，MONA，CLG4，EC 3.4.24
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 1 Clinical

MMP-2 Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Mouse (2)
Étiquette
His Tag (1)Fc Tag (1)
Marqueur
Unconjugated (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
MM2-M5253	Mouse	HEK293	Mouse MMP-2 Protein, Fc Tag (Pro-form, MALS verified)				Ajouter au panier
MM2-M52H9	Mouse	HEK293	Mouse MMP-2 (30-460) Protein, His Tag (Pro-form)				Ajouter au panier

Quantité totale2

MMP-2Contexte de la molécule

Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 / CLG4A contains 3 fibronectin type-II domains and 4 hemopexin-like domains. MMP-2 is produced by normal skin fibroblasts. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. MMP2 involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin.