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Page d'accueilToutes les moléculesNCAM-1
NCAM-1
NCAM-1 Informations sur la molécule
| Nom anglais | Neural cell adhesion molecule 1 | Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 6 | Alias de la cible | Neural cell adhesion molecule 1，CD56，NCAM1，NCAM，Neural Cell Adhesion Molecule， NCAM，CD56 Antigen，N-CAM-1，MSK39，NCAM-1，Antigen Recognized By Monoclonal Antibody 5.1H11 |
| Phase de R&D la plus avancée | Phase 2 Clinical | ||
| Nom anglais | Neural cell adhesion molecule 1 |
| Alias de la cible | Neural cell adhesion molecule 1，CD56，NCAM1，NCAM，Neural Cell Adhesion Molecule， NCAM，CD56 Antigen，N-CAM-1，MSK39，NCAM-1，Antigen Recognized By Monoclonal Antibody 5.1H11 |
| Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 6 |
| Phase de R&D la plus avancée | Phase 2 Clinical |
NCAM-1 Liste de produits
- Attribut
Protein (9)
- Bibliothèque de produits
En ligne (9)
- Espèces
Human (8)Mouse (1)
- Étiquette
His Tag (5)Fc Tag (2)His Tag & Avi Tag (1)Llama IgG Fc Tag (1)
- Marqueur
Unconjugated (4)Biotin-labeled (1)FITC Labeled (2)AF488 Labeled (1)AF647 Labeled (1)
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Quantité totale9
- 1
NCAM-1Contexte de la molécule
NCAM1 belongs to the immunoglobulin superfamily of adhesion molecules. A wide range of alternatively spliced NCAM1 messenger RNAs (mRNAs) has been described to date, but only the 120-, 140-, and 180- kDa isoforms are commonly expressed. NCAM1 plays an important role in the regulation of neurogenesis, neurite outgrowth, proliferation, and cell migration, however, its function in hematopoiesis, including NK cells, is poorly understood. NCAM1 signaling is mediated either by homophilic or heterophilic interactions with fibroblast growth factor receptor (FGFR), L1-CAM, N-cadherin and other components of the extracellular matrix. Upon activation, NCAM1 triggers a variety of signaling cascades including FYN–focal adhesion kinase (FAK), MAPK, and phosphatidylinositol 3-kinase (PI3K) pathways.
NCAM-1Alias de la molécule
CD56,MSK39,NCAM1,N-CAM-1
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Lorvotuzumab mertansine | BB-10901; IMGN-901; huN-901-DM1; IMGN-901-TAP; huN-901-SPP-DM1 | Phase 2 Clinical | Immunogen Inc | Carcinoma, Merkel Cell; Leukemia; Multiple Myeloma; Neuroblastoma; Neurofibrosarcoma; Ovarian Neoplasms; Pulmonary Blastoma; Rhabdomyosarcoma; Sarcoma, Synovial; Small Cell Lung Carcinoma; Wilms Tumor | Details |
| EB-DART-NK01 | EB-DART-NK01 | Phase 2 Clinical | Beijing Biotech | Small Cell Lung Carcinoma | Details |
| CUBT-906 | CUBT-906 | Phase 2 Clinical | Curative Biotechnology Inc | Glioblastoma | Details |
| GD2/CD56 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) | bi-4SCAR GD2/CD56 | Phase 2 Clinical | Shenzhen Geno-Immune Medical Institute | Neoplasms | Details |
| IN-B015 | IN-B-015; IN-B00004 | Phase 1 Clinical | HK inno.N Corporation | Neoplasms | Details |
| DXC-006 | DXC-006; DAC-006 | Phase 1 Clinical | Hangzhou Dac Biotech Company Ltd | Hematologic Neoplasms; Lung Neoplasms; Solid tumours | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments cliniques
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