Neprilysin

Neprilysin Informations sur la molécule

Nom anglais	Neprilysin	Nombre de médicaments commercialisés	3
Nombre de médicaments cliniques	8	Alias de la cible	EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase
Phase de R&D la plus avancée	Approved

Nom anglais	Neprilysin
Alias de la cible	EC:3.4.24.11，EC 3.4.24，Atriopeptidase，NEP，SFE，Membrane Metallo-Endopeptidase (Neutral Endopeptidase， Enkephalinase， CALLA， CD10)，Membrane Metallo-Endopeptidase Variant 1，Membrane Metallo-Endopeptidase Variant 2，Neprilysin-390，Neprilysin-411，CD10 Antigen，EC 3.4.24.11，CMT2T，SCA43，EPN，MME，Enkephalinase，CALLA，Neutral endopeptidase，Common acute lymphocytic leukemia antigen，Neprilysin，CD10，Membrane Metalloendopeptidase，Neutral Endopeptidase 24.11，Skin fibroblast elastase
Nombre de médicaments commercialisés	3
Nombre de médicaments cliniques	8
Phase de R&D la plus avancée	Approved

Neprilysin Liste de produits

Attribut
Protein (3)
Bibliothèque de produits
En ligne (3)
Espèces
Human (3)
Étiquette
Fc Tag (1)Tag Free (1)His Tag (1)
Marqueur
Unconjugated (3)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
MME-H521b	Human	HEK293	Human Neprilysin / MME / CD10 Protein, Tag Free (active enzyme)	Ajouter au panier
MME-H5243	Human	HEK293	Human Neprilysin / MME / CD10 Protein, His Tag (active enzyme, MALS verified)	Ajouter au panier
MME-H526a	Human	HEK293	Human Neprilysin / MME / CD10 Protein, Fc Tag	Ajouter au panier

Quantité totale3

NeprilysinContexte de la molécule

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

NeprilysinAlias de la molécule

MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Dexecadotril		Phase 3 Clinical	Bioprojet Pharma	Gastrointestinal Diseases	Details
Sacubitril/Valsartan (Chong Kun Dang Pharmaceutical)	CKD-202A	Phase 3 Clinical	Chong Kun Dang Pharmaceutical Corp	Essential Hypertension	Details
QR-12000	QR-12000	Phase 3 Clinical	Wuhan Createrna Science and Technology Co Ltd	Essential Hypertension; Hypertension	Details
Debio-0827	PL-37; Debio-0827	Phase 2 Clinical	Pharmaleads	Pain	Details
Sacubitril	AHU-377	Phase 2 Clinical	Novartis Pharma Ag	Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Diabetes Mellitus; Essential Hypertension; Heart Failure; Hypertension; Insulin Resistance; Metabolic Diseases	Details
Anti-CD10 CAR T-cell therapy (Zhujiang Hospital/Nanfang Hospital)		Phase 1 Clinical	Southern Medical University Zhujing Hospital	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Details
Sacubitril Valsartan Sodium Extended-Relesae Tablets(Taizhou Overseas Pharma)		Phase 1 Clinical	Taizhou Overseas Pharmaceuticals Co Ltd	Heart Failure	Details
Sacubitril/Allisartan Isoproxil/Amlodipine Besylate		Phase 1 Clinical	Shenzhen Salubris Pharmaceuticals Co Ltd	Essential Hypertension	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Sacubitril/Allisartan Isoproxil	AHU-377/EXP3174; S-086	Approved	Shenzhen Salubris Pharmaceuticals Co Ltd	信超妥	Mainland China	Essential Hypertension	Shenzhen Salubris Pharmaceuticals Co Ltd	2025-05-20	Essential Hypertension; Heart Failure; Hypertension	Details
Sacubitril/Valsartan Sodium Hydrate	LCZ-696; LCZ-696A	Approved	Novartis Pharma Ag	ENTRESTO SPRINKLE, Enresuto, Enrest, Entresto, Neparvis, 诺欣妥, 科畅欣	United States	Heart Failure	Novartis Pharmaceuticals Corp	2015-07-07	Breast Neoplasms; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Coronavirus Disease 2019 (COVID-19); Erectile Dysfunction; Essential Hypertension; Heart Defects, Congenital; Heart Diseases; Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic; Hepatic Insufficiency; Hypertension; Lymphoma; Myocardial Infarction; Obesity; Peripheral Arterial Disease; Postmyocardial Infarction Syndrome; Renal Insufficiency; Renal Insufficiency, Chronic; Ventricular Dysfunction, Left	Details
Racecadotril	Tiorfan; Hidrasec	Approved	Bioprojet Pharma		France	Diarrhea	Bioprojet Pharma	1993-03-23	Diarrhea; Diarrhea, Infantile; Sepsis	Details