NOTCH1

NOTCH1 Informations sur la molécule

Nom anglais	Neurogenic locus notch homolog protein 1	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
Phase de R&D la plus avancée	Phase 1 Clinical

Nom anglais	Neurogenic locus notch homolog protein 1
Alias de la cible	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 1 Clinical

NOTCH1 Liste de produits

Attribut
Protein (4)
Bibliothèque de produits
En ligne (4)
Espèces
Mouse (1)Human (3)
Étiquette
His Tag (2)Fc Tag (2)
Marqueur
Unconjugated (3)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT NO1-H52H3	Human	HEK293	Human NOTCH1 Protein, His Tag, premium grade	Ajouter au panier
NO1-H5255	Human	HEK293	Human NOTCH1 Protein, Fc Tag (MALS verified)	Ajouter au panier
NO1-H8253	Human	HEK293	Biotinylated Human NOTCH1 Protein, Fc Tag, ultra sensitivity (primary amine labeling)	Ajouter au panier
NO1-M52H8	Mouse	HEK293	Mouse NOTCH1 Protein, His Tag	Ajouter au panier

Quantité totale4

Demande de produit

NOTCH1Contexte de la molécule

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

NOTCH1Alias de la molécule

NOTCH1,Notch 1,hN1,TAN1

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Crenigacestat	JSMD-194; LY-3039478; BMS-986405	Phase 1 Clinical	Eli Lilly And Company	Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Cholangiocarcinoma; Colonic Neoplasms; Leiomyosarcoma; Leukemia, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Lymphoma; Lymphoma, B-Cell; Lymphoma, T-Cell; Multiple Myeloma; Neoplasm Metastasis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Solid tumours; Triple Negative Breast Neoplasms	Details