Osteoactivin
Osteoactivin Informations sur la molécule
| Nom anglais | Transmembrane glycoprotein NMB | Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 2 | Alias de la cible | Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925 |
| Phase de R&D la plus avancée | Phase 2 Clinical | ||
| Nom anglais | Transmembrane glycoprotein NMB |
| Alias de la cible | Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925 |
| Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 2 |
| Phase de R&D la plus avancée | Phase 2 Clinical |
Osteoactivin Liste de produits
- Attribut
Protein (1)
- Bibliothèque de produits
En ligne (1)
- Espèces
Human (1)
- Étiquette
His Tag (1)
- Marqueur
Unconjugated (1)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
 Human | HEK293 | Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin |  |  |  Ajouter au panier |
Quantité totale1
- 1
OsteoactivinContexte de la molécule
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
OsteoactivinAlias de la molécule
GPNMB,HGFIN,NMB,Osteoactivin
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Glembatumumab vedotin | CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE | Phase 2 Clinical | Celldex Therapeutics | Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma; Osteosarcoma; Skin Melanoma; Solid tumours; Triple Negative Breast Neoplasms; Uveal melanoma | Details |
| GPNMB-targeting Chimeric Antigen Receptor T-Cell Therapy (AHS Cancer Control Alberta) | GCAR1 | Phase 1 Clinical | AHS Cancer Control Alberta | Carcinoma, Renal Cell; Sarcoma; Sarcoma, Alveolar Soft Part; Triple Negative Breast Neoplasms | Details |
Avis sur les produits
A***c2026-02-27
0Mettre un likeThe Human Osteoactivin / GPNMB Protein, His Tag I purchased has been a reliable and useful reagent for interference testing. This reagent was optimal for work in both a PK and ADA assay. There have been no observed lot to lot differences, which is important in my line of work. I would recommend this product.
- Informations sur la molécule
- Liste de produits
- Avis sur les produits
- Informations sur les médicaments cliniques