Osteopontin

Osteopontin Informations sur la molécule

Nom anglais	Osteopontin	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0	Alias de la cible	Secreted Phosphoprotein 1 (Osteopontin， Bone Sialoprotein I， Early T-Lymphocyte Activation 1)，Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein，Secreted Phosphoprotein 1 Variant 6，SPP1/CALPHA1 Fusion，ETA-1，BSPI，SPP-1，Bone sialoprotein 1，BNSP，Urinary stone protein，PSEC0156，OPN，Uropontin，SPP1，Secreted Phosphoprotein 1，Early T-Lymphocyte Activation 1，Nephropontin，Osteopontin，Bone Sialoprotein I
Phase de R&D la plus avancée	Preclinical

Nom anglais	Osteopontin
Alias de la cible	Secreted Phosphoprotein 1 (Osteopontin， Bone Sialoprotein I， Early T-Lymphocyte Activation 1)，Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein，Secreted Phosphoprotein 1 Variant 6，SPP1/CALPHA1 Fusion，ETA-1，BSPI，SPP-1，Bone sialoprotein 1，BNSP，Urinary stone protein，PSEC0156，OPN，Uropontin，SPP1，Secreted Phosphoprotein 1，Early T-Lymphocyte Activation 1，Nephropontin，Osteopontin，Bone Sialoprotein I
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0
Phase de R&D la plus avancée	Preclinical

Osteopontin Liste de produits

Attribut
Protein (3)
Bibliothèque de produits
En ligne (3)
Espèces
Human (2)Mouse (1)
Étiquette
His Tag (1)His Tag & Avi Tag (2)
Marqueur
Unconjugated (1)Biotin-labeled (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
OPN-H5227	Human	HEK293	Human Osteopontin (OPN) Protein, His Tag, premium grade	Ajouter au panier
OPN-H82E8	Human	HEK293	Biotinylated Human Osteopontin (OPN) Protein, His,Avitag™	Ajouter au panier
OPN-M82E8	Mouse	HEK293	Biotinylated Mouse Osteopontin (OPN) Protein, His,Avitag™	Ajouter au panier

Quantité totale3

OsteopontinContexte de la molécule

Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.