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OX40 Ligand
OX40 Ligand Overview
| English Name | Tumor necrosis factor ligand superfamily member 4 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 13 | Target Synonym | CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Necrosis Factor Ligand 2B，OX40 Antigen Ligand |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Tumor necrosis factor ligand superfamily member 4 |
| Target Synonym | CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Necrosis Factor Ligand 2B，OX40 Antigen Ligand |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 13 |
| Highest Development Stage | Phase 3 Clinical |
OX40 Ligand Product List
- Product Category
Protein (17)Cell (1)
- Product Status
Launched (18)
- Species
Human (8)Mouse (4)Cynomolgus / Rhesus macaque (3)Rabbit (1)Rat (1)Canine (1)
- Tag
His Tag (8)Mouse IgG Fc Tag (2)Avi Tag & Fc Tag (2)Fc Tag (2)His Tag & Avi Tag (3)- (1)
- Conjugate
Unconjugated (12)Biotin-labeled (5)- (1)
Total: 18
- 1
- 2
OX40 Ligand Background
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
OX40 Ligand Synonyms
OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Amlitelimab | KY-1005; SAR-445229 | Phase 3 Clinical | Kymab Ltd, Sanofi | Alopecia Areata; Asthma; Celiac Disease; Dermatitis, Atopic; Eczema; Hidradenitis; Immune System Diseases; Lung Diseases, Interstitial; Scleroderma, Systemic | Details |
| APG-279 | APG279; APG-990/APG777 | Phase 2 Clinical | Apogee Therapeutics Inc | Dermatitis, Atopic | Details |
| IMB-101 (IMBiologics) | IMB-101 (IMBiologics); HDM-3019; IMB101 (IMBiologics); HDM3019; NAV-240 | Phase 2 Clinical | IMBiologics Corp | Arthritis, Rheumatoid; Hidradenitis Suppurativa | Details |
| IBI356 | IBI-356; IBI356 | Phase 2 Clinical | Autoimmune Diseases; Dermatitis, Atopic | Details | |
| RP-3 | RP-3 | Phase 2 Clinical | Replimune Inc | Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck | Details |
| HS-130 | HS-130 | Phase 1 Clinical | Heat Biologics | Solid tumours | Details |
| mRNA-2752 | mRNA-2752 | Phase 1 Clinical | Astrazeneca Plc, Moderna Inc | Lymphoma; Neoplasms; Solid tumours | Details |
| MQ-710 | MQ-710 | Phase 1 Clinical | Imvaq Therapeutics Corp, Memorial Sloan Kettering Cancer Center | Adenocarcinoma, Sebaceous; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Carcinoma, Merkel Cell; Carcinoma, Squamous Cell; Hemangiosarcoma; Melanoma; Neoplasm Metastasis; Neoplasms; Paget Disease, Extramammary; Sarcoma, Kaposi; Solid tumours; Squamous Cell Carcinoma of Head and Neck | Details |
| OX-118 | OX-118 | Phase 1 Clinical | Oxion Biologics AB | Autoimmune Diseases; Immune System Diseases; Rheumatic Diseases | Details |
| M-5542 | M5542; M-5542 | Phase 1 Clinical | Merck & Co Inc | Details | |
| ABCL-575 | ABCL-575; ABCL575 | Phase 1 Clinical | AbCellera Biologics Inc | Dermatitis, Atopic | Details |
| APG-990 | APG-990; APG990; PR-007; PR007 | Phase 1 Clinical | Paragon Therapeutics Inc | Dermatitis, Atopic | Details |
| SAR-443726 | SAR-443726 | Phase 1 Clinical | Sanofi | Dermatitis, Atopic | Details |
- Overview
- Product List
- Clinical Drug Information
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