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Page d'accueilToutes les moléculesProgranulin
Progranulin
Progranulin Informations sur la molécule
| Nom anglais | Progranulin | Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 7 | Alias de la cible | GRN |
| Phase de R&D la plus avancée | Phase 2 Clinical | ||
| Nom anglais | Progranulin |
| Alias de la cible | GRN |
| Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 7 |
| Phase de R&D la plus avancée | Phase 2 Clinical |
Progranulin Liste de produits
- Attribut
Protein (1)
- Bibliothèque de produits
En ligne (1)
- Espèces
Human (1)
- Étiquette
His Tag (1)
- Marqueur
Unconjugated (1)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
PGN-H52H3 |  Human | HEK293 | Human Progranulin Protein, His Tag, low endotoxin (MALS & SPR verified) |  |  |  |  Ajouter au panier |
Quantité totale1
- 1
ProgranulinContexte de la molécule
Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene. Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 cysteine granulin motif. Many cellular processes and diseases are associated with this unique pleiotropic factor that include, but are not limited to, embryogenesis, tumorigenesis, inflammation, wound repair, neurodegeneration and lysosome function. Haploinsufficiency caused by autosomal dominant mutations within the GRN gene leads to frontotemporal lobar degeneration, a progressive neuronal atrophy that presents in patients as frontotemporal dementia.
ProgranulinAlias de la molécule
CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| GRN Gene Therapy（Eli Lilly And Company） | PR-006; LY3884963 | Phase 2 Clinical | Eli Lilly And Company | Frontotemporal Dementia | Details |
| TAK-594 | DNL-593; PTV:PGRN; TAK-594 | Phase 2 Clinical | Denali Therapeutics Inc | Frontotemporal Dementia | Details |
| AVB-101 | AVB-101 | Phase 2 Clinical | AviadoBio Ltd | Frontotemporal Dementia | Details |
| Nivisnebart | AL-101; GSK-4527226 | Phase 2 Clinical | Alector Inc | Alzheimer Disease; Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Nerve Degeneration; Parkinson Disease | Details |
| PBFT-02 | PBFT-02 | Phase 2 Clinical | University Of Pennsylvania | Frontotemporal Dementia | Details |
| VGN-R13 | VGN-R13 | Phase 1 Clinical | Shanghai Vitalgen BioPharma Co Ltd | Amyotrophic Lateral Sclerosis | Details |
| AG-01（A&G Pharm） | AG-01（A&G Pharm） | Phase 1 Clinical | A&G Pharmaceutical | Carcinoma, Non-Small-Cell Lung; Mesothelioma; Triple Negative Breast Neoplasms | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments cliniques
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