Prolactin R
Prolactin R Informations sur la molécule
| Nom anglais | Prolactin receptor | Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 2 | Alias de la cible | PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin |
| Phase de R&D la plus avancée | Phase 3 Clinical | ||
| Nom anglais | Prolactin receptor |
| Alias de la cible | PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin |
| Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 2 |
| Phase de R&D la plus avancée | Phase 3 Clinical |
Prolactin R Liste de produits
- Attribut
Protein (7)
- Bibliothèque de produits
En ligne (7)
- Espèces
Human (4)Cynomolgus (1)Rat (1)Mouse (1)
- Étiquette
Fc Tag (1)His Tag (5)His Tag & Avi Tag (1)
- Marqueur
Unconjugated (6)Biotin-labeled (1)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
 Human | HEK293 | Human Prolactin R / PRLR Protein, Fc Tag |  |  |  |  Ajouter au panier | |
| Human | HEK293 | Human Prolactin R / PRLR Protein, His Tag&Tag Free, low endotoxin (MALS verified) | | | Ajouter au panier | ||
| Human | HEK293 | Human Prolactin R / PRLR Protein, His Tag |  | | | Ajouter au panier | |
| Human | HEK293 | Biotinylated Human Prolactin R / PRLR Protein, His,Avitag™ (MALS verified) |  | | | Ajouter au panier | |
 Mouse | HEK293 | Mouse Prolactin R / PRLR Protein, His Tag (MALS & SPR verified) |  | |  | Ajouter au panier | |
 Cynomolgus | HEK293 | Cynomolgus Prolactin R Protein, His Tag (MALS verified) |  | | | Ajouter au panier | |
 Rat | HEK293 | Rat Prolactin R / PRLR Protein, His Tag (MALS & SPR verified) |  | | | Ajouter au panier |
Quantité totale7
- 1
Prolactin RContexte de la molécule
The prolactin receptor (PRLR) is a transmembrane protein belonging to the class I cytokine receptor superfamily, widely expressed in mammary gland, reproductive organs, liver, and brain. Signal activation is initiated when a single prolactin (PRL) molecule binds to this pre-dimerized PRLR, inducing a specific conformational change. This triggers the associated JAK2 kinases to phosphorylate each other and the receptor, ultimately leading to the recruitment and activation of downstream STAT5 transcription factors. This precise mechanism governs essential physiological processes, including lactation, reproduction, metabolism, and immune function, and its dysregulation is implicated in diseases such as certain cancers and endometriosis.
Prolactin RAlias de la molécule
Prolactin R,PRLR,PRL-R
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| BAY-1158061 | BAY-1158061; HMI-115 | Phase 3 Clinical | Bayer AG | Alopecia; Endometriosis; Pain | Details |
| ABS-201 | ABS-201 | Phase 2 Clinical | Absci Corp | Alopecia; Skin Diseases | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments cliniques