R-Spondin 3

R-Spondin 3 Informations sur la molécule

Nom anglais	R-spondin-3	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0	Alias de la cible	Thrombospondin Type-1 Domain-Containing Protein 2，Thrombospondin， Type I， Domain Containing 2，Protein With TSP Type-1 Repeat，PWTSR，R-Spondin 3 Homolog (Xenopus Laevis)，R-Spondin 3 Homolog，R-Spondin-3，CRISTIN1，HRspo3，FLJ14440，Roof plate-specific spondin-3，RSPO3，hPWTSR，THSD2，R-Spondin 3
Phase de R&D la plus avancée	Preclinical

Nom anglais	R-spondin-3
Alias de la cible	Thrombospondin Type-1 Domain-Containing Protein 2，Thrombospondin， Type I， Domain Containing 2，Protein With TSP Type-1 Repeat，PWTSR，R-Spondin 3 Homolog (Xenopus Laevis)，R-Spondin 3 Homolog，R-Spondin-3，CRISTIN1，HRspo3，FLJ14440，Roof plate-specific spondin-3，RSPO3，hPWTSR，THSD2，R-Spondin 3
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	0
Phase de R&D la plus avancée	Preclinical

R-Spondin 3 Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Human (2)
Étiquette
His Tag (1)Fc Tag (1)
Marqueur
Unconjugated (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
RS3-H5253	Human	HEK293	Human R-Spondin 3 / RSPO3 Protein, Fc Tag				Ajouter au panier
RS6-H5222	Human	HEK293	Human R-Spondin 3 / RSPO3 (22-146) Protein, His Tag				Ajouter au panier

Quantité totale2

R-Spondin 3Contexte de la molécule

R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.