ROCK1

ROCK1 (Rho-associated coiled-coil containing protein kinase 1) is a critical serine/threonine kinase that functions as a key downstream effector of the small GTPase RhoA. It plays a fundamental role in regulating cytoskeleton organization, actomyosin contractility, and cell motility. ROCK1 is vital for diverse biological processes, including cell adhesion, cytokinesis, and apoptosis, making it a significant target in cancer and cardiovascular research.