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ROR1

ROR1 Overview

English NameInactive tyrosine-protein kinase transmembrane receptor ROR1Approved Drugs0
Drugs in Clinical Trials19Target SynonymEC 2.7.10.1，Inactive tyrosine-protein kinase transmembrane receptor ROR1，NTRKR1，ROR1，Receptor Tyrosine Kinase Like Orphan Receptor 1，Neurotrophic Tyrosine Kinase， Receptor-Related 1，DJ537F10.1，ROR-1
Highest Development StagePhase 3 Clinical
English NameInactive tyrosine-protein kinase transmembrane receptor ROR1
Target SynonymEC 2.7.10.1，Inactive tyrosine-protein kinase transmembrane receptor ROR1，NTRKR1，ROR1，Receptor Tyrosine Kinase Like Orphan Receptor 1，Neurotrophic Tyrosine Kinase， Receptor-Related 1，DJ537F10.1，ROR-1
Approved Drugs0
Drugs in Clinical Trials19
Highest Development StagePhase 3 Clinical

ROR1 Product List

  • Product Category

    Protein (20)Beads (1)Cell (2)

  • Product Status

    Launched (23)In Research (1)

  • Species

    Human / Cynomolgus / Rhesus macaque (9)Mouse (4)Rat (1)Human (9)

  • Tag

    Fc Tag (3)His Tag (11)Fc Tag & Avi Tag (2)Avi Tag (1)His Tag & Avi Tag (2)- (4)Mouse IgG Fc Tag (1)

  • Conjugate

    Unconjugated (9)Biotin-labeled (5)- (4)FITC Labeled (2)PE Labeled (2)AF488 Labeled (1)APC Labeled (1)

Total: 23
  • 1
  • 2
  • 3

ROR1 Background

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

ROR1 Synonyms

ROR1,NTRKR1

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