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S100B

S100B Overview

English Name	Protein Nef	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	nef，Negative factor，3'ORF，Protein Nef，F-protein
Highest Development Stage	Phase 1 Clinical

English Name	Protein Nef
Target Synonym	nef，Negative factor，3'ORF，Protein Nef，F-protein
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

S100B Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
S1B-H5143	Human	E. coli	Human S100B Protein, His Tag

Total: 1

S100B Background

S-100 protein beta chain (S100B),a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction,S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore,S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

S100B Synonyms

S100B,NEF,S100,S100beta

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
HIV clade B mRNA dendritic cell therapy (Immunomic Therapeutics/Universite Libre de Bruxelles)		Phase 1 Clinical	Immunomic Therapeutics Inc	HIV Infections	Details