SDF-1
SDF-1 Informations sur la molécule
| Nom anglais | C-X-C motif chemokine ligand 12 | Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 5 | Alias de la cible | Pre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A |
| Phase de R&D la plus avancée | Phase 2 Clinical | ||
| Nom anglais | C-X-C motif chemokine ligand 12 |
| Alias de la cible | Pre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A |
| Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 5 |
| Phase de R&D la plus avancée | Phase 2 Clinical |
SDF-1 Liste de produits
- Attribut
Protein (4)
- Bibliothèque de produits
En ligne (4)
- Espèces
Human (4)
- Étiquette
His Tag (1)Tag Free (3)
- Marqueur
Unconjugated (4)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
HOT GMP-SD1H13 |  Human | E. coli | GMP Human SDF-1 / CXCL12 Protein |  |  |  Ajouter au panier | |
| Human | E. coli | Human SDF-1 / CXCL12 Protein, premium grade |  | |  | Ajouter au panier | |
| Human | E. coli | Human SDF-1 / CXCL12 Protein, Research Grade |  | | | Ajouter au panier | |
| Human | E. coli | Human SDF-1 / CXCL12 Protein, His Tag (HPLC & SPR verified) |  | |  | Ajouter au panier |
Quantité totale4
- 1
SDF-1Contexte de la molécule
Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells
SDF-1Alias de la molécule
SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Olaptesed Pegol | NOX-A12 | Phase 2 Clinical | Noxxon Pharma | Colorectal Neoplasms; Glioblastoma; Hematopoietic stem cell transplantation (HSCT); Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma; Pancreatic Neoplasms | Details |
| PTX-9908 | PTX-9908 | Phase 2 Clinical | Pertinax Therapeutics | Carcinoma, Hepatocellular | Details |
| JVS-100 | JVS-100; SRX-100; ACRX-100; GP-51801; GP51801 | Phase 1 Clinical | Cleveland Clinic | Heart Failure; Ischemia; Peripheral Arterial Disease; Surgical Wound | Details |
| CK-0804 | CK-08041; CK-0804 | Phase 1 Clinical | Cellenkos Inc | Primary Myelofibrosis | Details |
| MyoCell SDF-1 | MyoCell SDF-1 | Clinical | U.S. Stem Cell | Heart Failure | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments cliniques