Siglec-15

Siglec-15 Informations sur la molécule

Nom anglais	Sialic acid-binding Ig-like lectin 15	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3	Alias de la cible	SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Sialic acid-binding Ig-like lectin 15
Alias de la cible	SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Phase 2 Clinical

Siglec-15 Liste de produits

Attribut
Protein (7)
Bibliothèque de produits
En ligne (7)
Espèces
Human (4)Rhesus macaque (1)Mouse (1)Rat (1)
Étiquette
Fc Tag (1)His Tag (4)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)
Marqueur
Unconjugated (5)Biotin-labeled (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT SG5-H5253	Human	HEK293	Human Siglec-15 / CD33L3 Protein, Fc Tag	Ajouter au panier
HOT SG5-H52H3	Human	HEK293	Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)	Ajouter au panier
HOT SG5-H82E9	Human	HEK293	Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag™ (recommended for biopanning)	Ajouter au panier
HOT SG5-H82F5	Human	HEK293	Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag™	Ajouter au panier
SG5-M52H7	Mouse	HEK293	Mouse Siglec-15 / CD33L3 Protein, His Tag	Ajouter au panier
SG5-C52H6	Rhesus macaque	HEK293	Rhesus macaque Siglec-15 / CD33L3 Protein, His Tag	Ajouter au panier
SG5-R52H3	Rat	HEK293	Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified)	Ajouter au panier

Quantité totale7

Siglec-15Contexte de la molécule

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Siglec-15Alias de la molécule

CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
NC-318	NC-318; 5G-12	Phase 2 Clinical	Yale School Of Medicine	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Lung Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
DS-1501	DS-1501	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Osteoporosis	Details
BSI-060T	PYX-106; BSI-060T	Phase 1 Clinical	Biosion Inc	Neoplasm Metastasis; Solid tumours	Details

Avis sur les produits

1***22019-10-11
6Mettre un like
Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
Siglec-15 is a relatively new type of immune checkpoint molecule. In the process of antibody molecule screening, we used ACRO's Siglec-15 antigen. It has shown very good stability in protein-level binding experiments, and the bioactivity was also quite good which was verified in functional experiments.
1***32019-10-11
1Mettre un like
Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
The product is pretty good and the price is competitive. Besides, the delivery was fast. In particular, there is a literature introduction cited the product. It is obvious that each target has been carefully studied.
1***22019-10-12
8Mettre un like
Human Siglec-15 / CD33L3 Protein, Fc Tag
We can obtain a good inhibitory effect using this protein to verify its inhibitory on T-cells functions. S15-hFc protein can effectively inhibit the secretion of IFN-gamma stimulated by OKT3 in CD4 + T cells.