Siglec-15 Overview
Molecule Name
Sialic acid-binding Ig-like lectin 15
Synonyms
CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15
Drug Development Progress
Drugs in Clinical Trials3
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
Background
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
Siglec-15 Product List
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1***22019-10-11Siglec-15 is a relatively new type of immune checkpoint molecule. In the process of antibody molecule screening, we used ACRO's Siglec-15 antigen. It has shown very good stability in protein-level binding experiments, and the bioactivity was also quite good which was verified in functional experiments.- 1***32019-10-11The product is pretty good and the price is competitive. Besides, the delivery was fast. In particular, there is a literature introduction cited the product. It is obvious that each target has been carefully studied.
- 1***22019-10-12We can obtain a good inhibitory effect using this protein to verify its inhibitory on T-cells functions. S15-hFc protein can effectively inhibit the secretion of IFN-gamma stimulated by OKT3 in CD4 + T cells.