Siglec-8

Siglec-8 Informations sur la molécule

Nom anglais	Sialic acid-binding Ig-like lectin 8	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
Phase de R&D la plus avancée	Phase 3 Clinical

Nom anglais	Sialic acid-binding Ig-like lectin 8
Alias de la cible	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 3 Clinical

Siglec-8 Liste de produits

Attribut
Protein (3)
Bibliothèque de produits
En ligne (3)
Espèces
Human (3)
Étiquette
His Tag (1)Fc Tag (1)His Tag & Avi Tag (1)
Marqueur
Unconjugated (2)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT SI8-H52H8	Human	HEK293	Human Siglec-8 Protein, His Tag, low endotoxin (MALS verified)	Ajouter au panier
SI8-H5254	Human	HEK293	Human Siglec-8 Protein, Fc Tag	Ajouter au panier
SI8-H82E9	Human	HEK293	Biotinylated Human Siglec-8 Protein, His,Avitag™	Ajouter au panier

Quantité totale3

Siglec-8Contexte de la molécule

Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8Alias de la molécule

Siglec-8,SAF-2,SIGLEC8,SAF2

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
AK-001	AK-001	Phase 3 Clinical	Allakos Inc	Community Acquired Pneumonia; Hypersensitivity; Nasal Polyps; Respiratory Tract Infections; Urinary Tract Infections	Details