SMO

SMO Informations sur la molécule

Nom anglais	Smoothened receptor	Nombre de médicaments commercialisés	3
Nombre de médicaments cliniques	5	Alias de la cible	SMO，SMOH，Smoothened， Frizzled Class Receptor，Smoothened， Frizzled Family Receptor，Frizzled Family Member 11，Protein Gx，Seven Transmembrane Helix Receptor，Smoothened Homolog (Drosophila)，Smoothened Homolog，FZD11，CRJS，Gx，Smoothened Receptor，Smoothened， Seven Transmembrane Spanning Receptor，Smoothened (Drosophila) Homolog
Phase de R&D la plus avancée	Approved

Nom anglais	Smoothened receptor
Alias de la cible	SMO，SMOH，Smoothened， Frizzled Class Receptor，Smoothened， Frizzled Family Receptor，Frizzled Family Member 11，Protein Gx，Seven Transmembrane Helix Receptor，Smoothened Homolog (Drosophila)，Smoothened Homolog，FZD11，CRJS，Gx，Smoothened Receptor，Smoothened， Seven Transmembrane Spanning Receptor，Smoothened (Drosophila) Homolog
Nombre de médicaments commercialisés	3
Nombre de médicaments cliniques	5
Phase de R&D la plus avancée	Approved

SMO Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Human (2)
Étiquette
- (2)
Marqueur
Unconjugated (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
SMO-H52D3	Human	HEK293	Human SMO Protein, His,Flag Tag (Detergent)				Ajouter au panier
SMO-H52P3	Human	HEK293	Human SMO Full Length Protein (VLP)				Ajouter au panier

Quantité totale2

SMOContexte de la molécule

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.

SMOAlias de la molécule

SMO,smoothened, frizzled class receptor,CRJS, FZD11, Gx, PHLS, SMOH

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Patidegib	SGT-610; BBP-009; FIN-5; IPI-926	Phase 3 Clinical	Infinity Pharmaceuticals Inc	Adenocarcinoma; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Chondrosarcoma; Head and Neck Neoplasms; Neoplasms; Pancreatic Neoplasms; Primary Myelofibrosis	Details
Taladegib	ENV-IPF-101; ENV-ONC-101; LY-2940680; ENV-101; RXDX-109	Phase 2 Clinical	Eli Lilly And Company	Breast Neoplasms; Cholangiocarcinoma; Colonic Neoplasms; Idiopathic Pulmonary Fibrosis; Medulloblastoma; Neoplasm Metastasis; Neoplasms; Rhabdomyosarcoma; Sarcoma; Small Cell Lung Carcinoma; Solid tumours	Details
GT-1708F	GT-1708F; GT-1708; GT1708F	Phase 2 Clinical	Suzhou Koshine Biomedica Inc	Hematologic Neoplasms; Idiopathic Pulmonary Fibrosis; Solid tumours	Details
Cipromedegib	SHR-1539	Phase 1 Clinical	Jiangsu Hengrui Medicine Co Ltd	Solid tumours	Details
ZSP-1602	ZSP-1602	Phase 1 Clinical	Guangdong Zhongsheng Pharmaceutical Co Ltd	Carcinoma; Carcinoma, Basal Cell; Carcinoma, Neuroendocrine; Esophageal Neoplasms; Glioblastoma; Glioma; Medulloblastoma; Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Sonidegib Diphosphate	LDE-225; NVP-LDE-225	Approved	Novartis Pharma Ag	Odomzo, 奥昔朵	United States	Carcinoma, Basal Cell	Sun Pharmaceutical Industries Ltd	2015-07-24	Astrocytoma; Basal Cell Nevus Syndrome; Blood Coagulation Disorders; Blood Platelet Disorders; Bone Marrow Diseases; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Glioblastoma; Glioma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Hemorrhagic Disorders; Hepatic Insufficiency; Hepatoblastoma; HR-positive breast cancer; Leukemia; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Dysfunction; Lung Neoplasms; Medulloblastoma; Metastatic breast cancer; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neuroblastoma; Ovarian Neoplasms; Pancreatic Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Prostatic Neoplasms; Rhabdomyosarcoma; Skin Neoplasms; Solid tumours; Stomach Neoplasms; Thrombocythemia, Essential; Thrombocytosis;	Details
Glasdegib	PF-04; PF-4449913; PF-04449913	Approved	Pfizer Inc	Daurismo	United States	Leukemia, Myeloid, Acute	Pfizer Inc	2018-11-21	Fasciitis; Graft vs Host Disease; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Primary Myelofibrosis; Renal Insufficiency; Solid tumours	Details
Vismodegib	R-3616; RG-3616; GDC-0449	Approved	F. Hoffmann-La Roche Ltd, Genentech Inc	Erivedge	United States	Carcinoma, Basal Cell	Genentech Inc	2012-01-30	Adenocarcinoma; Basal Cell Nevus Syndrome; Brain Neoplasms; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Lymphoma; Chondrosarcoma; Chondrosarcoma, Clear Cell; Chondrosarcoma, Extraskeletal Myxoid; Chondrosarcoma, Mesenchymal; Colorectal Neoplasms; Dermatofibrosarcoma; Desmoplastic Small Round Cell Tumor; Esophageal Neoplasms; Fibrosarcoma; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Graft vs Host Disease; Hemangioendothelioma, Epithelioid; Hemangiosarcoma; Hematologic Neoplasms; Idiopathic Pulmonary Fibrosis; Leiomyosarcoma; Leukemia, Lymphocytic, Chronic, B-Cell; Liposarcoma; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Medulloblastoma; Mesenchymoma; Multiple Myeloma; Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Neurofibrosarcoma; Odontogenic Cyst, Calcifying; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma; Sarcoma, Alveolar Soft Part	Details