Sortilin

Sortilin Informations sur la molécule

Nom anglais	Sortilin	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3	Alias de la cible	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Sortilin
Alias de la cible	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Phase 2 Clinical

Sortilin Liste de produits

Attribut
Protein (5)Cell (1)
Bibliothèque de produits
En ligne (6)
Espèces
Human (3)Cynomolgus (1)Rat (1)Canine (1)
Étiquette
His Tag (4)His Tag & Avi Tag (1)- (1)
Marqueur
Unconjugated (4)Biotin-labeled (1)- (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
CHEK-ATP155	Human	HEK293	HEK293/Human SORT1 Stable Cell Line	Ajouter au panier
SON-H52H5	Human	HEK293	Human Sortilin / SORT1 Protein, His Tag, low endotoxin (MALS verified)	Ajouter au panier
SON-H82E9	Human	HEK293	Biotinylated Human Sortilin / SORT1 Protein, His,Avitag™ (MALS & SPR verified)	Ajouter au panier
SON-C52H3	Cynomolgus	HEK293	Cynomolgus Sortilin Protein, His Tag	Ajouter au panier
SON-C52H4	Canine	HEK293	Canine Sortilin Protein, His Tag	Ajouter au panier
SON-R52H3	Rat	HEK293	Rat Sortilin Protein, His Tag (MALS verified)	Ajouter au panier

Quantité totale6

SortilinContexte de la molécule

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

SortilinAlias de la molécule

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
VES-001	VES001; VES-001	Phase 2 Clinical	Vesper Bio APS	Dementia; Frontotemporal Dementia; Frontotemporal Lobar Degeneration	Details
Latozinemab	AL-001; GSK-4527223	Phase 1 Clinical	Alector Inc, Glaxosmithkline Plc	Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Neurodegenerative Diseases	Details
ARB-1-6	ARB-1-6; PQ-203	Phase 1 Clinical	ProteinQure Inc	Breast Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details