TFPI-2

TFPI-2 Informations sur la molécule

Nom anglais	DNA-(apurinic or apyrimidinic site) lyase	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	DNA-(apurinic or apyrimidinic site) lyase
Alias de la cible	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 2 Clinical

TFPI-2 Liste de produits

Attribut
Protein (1)
Bibliothèque de produits
En ligne (1)
Espèces
Human (1)
Étiquette
His Tag (1)
Marqueur
Unconjugated (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
TF2-H5227	Human	HEK293	Human TFPI-2 Protein, His Tag				Ajouter au panier

Quantité totale1

TFPI-2Contexte de la molécule

Tissue Factor Pathway Inhibitor 2 (TFPI2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.

TFPI-2Alias de la molécule

TFPI2,PP5,REF1

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
APX-3330	APX-3330; APX3330; E-3330	Phase 2 Clinical	Eisai Co Ltd	Solid tumours; Inflammatory Bowel Diseases; Neoplasms; Diabetic macular oedema; Diabetic Retinopathy	Details