TGF-beta 1

TGF-beta 1 Informations sur la molécule

Nom anglais	Transforming growth factor beta 1	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	22	Alias de la cible	Latency-Associated Peptide，IBDIMDE，Transforming Growth Factor beta1，Prepro-Transforming Growth Factor Beta-1，TGF-Beta-1，Transforming Growth Factor， Beta 1，CED，TGFB，DPD1，TGFB1，Transforming Growth Factor Beta-1 Proprotein，Camurati-Engelmann Disease，LAP，TGFbeta，Transforming Growth Factor Beta 1，Diaphyseal Dysplasia 1， Progressive，TGF-Beta1
Phase de R&D la plus avancée	Approved

Nom anglais	Transforming growth factor beta 1
Alias de la cible	Latency-Associated Peptide，IBDIMDE，Transforming Growth Factor beta1，Prepro-Transforming Growth Factor Beta-1，TGF-Beta-1，Transforming Growth Factor， Beta 1，CED，TGFB，DPD1，TGFB1，Transforming Growth Factor Beta-1 Proprotein，Camurati-Engelmann Disease，LAP，TGFbeta，Transforming Growth Factor Beta 1，Diaphyseal Dysplasia 1， Progressive，TGF-Beta1
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	22
Phase de R&D la plus avancée	Approved

TGF-beta 1 Liste de produits

Attribut
Protein (8)Cell (1)
Bibliothèque de produits
En ligne (9)
Espèces
Human (6)Mouse / Rat (3)
Étiquette
Tag Free (6)Avi Tag (2)- (1)
Marqueur
Unconjugated (6)Biotin-labeled (2)- (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT GMP-TG1H25	Human	HEK293	GMP Human TGF-Beta 1 / TGFB1 Protein	Ajouter au panier
HOT TG1-H4212	Human	HEK293	Human TGF-Beta 1 / TGFB1 Protein, Tag Free	Ajouter au panier
HOT TG1-H5218	Human	HEK293	Human TGF-Beta 1 / TGFB1 Protein, premium grade	Ajouter au panier
HOT TG1-H8217	Human	HEK293	Biotinylated Human TGF-Beta 1 / TGFB1 Protein, Avitag™	Ajouter au panier
CHEK-ATF145	Human	HEK293	Human TGF-beta R (Luc) HEK293 Reporter Cell	Ajouter au panier
TG1-H5219	Human	HEK293	Human TGF-Beta 1 / TGFB1 Protein, Research Grade	Ajouter au panier
TG1-M5218	Mouse / Rat	HEK293	Mouse / Rat TGF-Beta 1 / TGFB1 Protein, Tag Free	Ajouter au panier
TG1-M5313	Mouse / Rat	CHO	Mouse / Rat TGF-Beta 1 / TGFB1 Protein, Tag Free (HPLC verified)	Ajouter au panier
TG1-M8313	Mouse / Rat	CHO	Biotinylated Mouse / Rat TGF-Beta 1 / TGFB1 Protein, Avitag™	Ajouter au panier

Quantité totale9

TGF-beta 1Contexte de la molécule

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]

TGF-beta 1Alias de la molécule

CEDLAP,TGF-beta 1,TGFB1,DPD1,TGF-beta-1,TGFB

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Vactosertib	TEW-7197; EW-7197; NOV-1301	Phase 3 Clinical	Medpacto Inc	Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Melanoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Osteosarcoma; Solid tumours; Stomach Neoplasms; Urologic Neoplasms	Details
Bintrafusp alfa	M-7824; GSK-4045154; MSB-0011359C	Phase 3 Clinical	Merck Serono	Anus Neoplasms; Biliary Tract Neoplasms; Brain metastases; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Small Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Esthesioneuroblastoma, Olfactory; Gallbladder Neoplasms; Ganglioglioma; Head and Neck Neoplasms; Hematologic Neoplasms; Intestinal Neoplasms; Lung Neoplasms; Lymphoma; Melanoma; Metastatic breast cancer; Microsatellite Instability; Nasopharyngeal Carcinoma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Nose Neoplasms; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Papillomavirus Infections; Penile Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Respiratory papillomatosis; Sarcoma; Sarcoma, Kaposi; Skin Melanoma; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thymic epithelial tumor; Thymoma; Thymus Neoplasms; Triple Negative Breast Neop	Details
Nisevokitug	NIS-793	Phase 3 Clinical	Xoma Corp	Adenocarcinoma; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Kidney Neoplasms; Lung Neoplasms; Myelodysplastic Syndromes; Pancreatic Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential	Details
Yinfenidone Hydrochloride	HEC-585; HEC-00000585	Phase 3 Clinical	Hec Pharm Co Ltd	Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis	Details
SB-01 (Ensol BioSciences)	Peniel-2000; SB-01; Peniel 2K; YH14618; YH-14618; P2K	Phase 3 Clinical	Ensol Biosciences Inc	Intervertebral Disc Degeneration; Intervertebral disc disease; Low Back Pain	Details
Livmoniplimab	MGH-8; AGRX-115; ABBV-151; MHG-8; ARGX-115	Phase 3 Clinical	Argenx Se	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Solid tumours	Details
Dalutrafusp alfa	GS-1423; AGEN-1423	Phase 2 Clinical	Agenus Inc	Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Liver Neoplasms; Pancreatic Neoplasms; Solid tumours	Details
ZSP-1603	ZSP-1603	Phase 2 Clinical	Guangdong Zhongsheng Pharmaceutical Co Ltd, Wuxi Apptec Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Idiopathic Pulmonary Fibrosis; Liver Neoplasms; Ovarian Neoplasms; Solid tumours; Thyroid Neoplasms	Details
Nicousamide	XLF-III-43	Phase 2 Clinical	Institue Of Materia Medica Chinese Academy Of Medical Science	Diabetic Nephropathies; Hypertensive nephropathy	Details
Meflonidone hydrochloride		Phase 2 Clinical	Central South University, Guangzhou Nanxin Pharma Co Ltd	Diabetes Mellitus, Type 2; Diabetic Nephropathies	Details
Fluorofenidone	AKF-PD	Phase 2 Clinical	Central South University, Dierepharma HK Ltd, Hainan Haiyao Co Ltd	Hepatitis B, Chronic; Liver Cirrhosis	Details
Cotsiranib	STP-705LU; STP-705LV; STP-705; STP-705L	Phase 2 Clinical	Sirnaomics, Sirnaomics Biopharmaceuticals (Suzhou) Co Ltd	Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cicatrix, Hypertrophic; Keloid; Liver Neoplasms; Obesity, Abdominal	Details
YL-13027	YL-13027	Phase 2 Clinical	YL-Pharma	Pancreatic Neoplasms; Solid tumours	Details
MR-001	MR001; MR-001	Phase 2 Clinical	Shenzhen Maijiarui Biotechnology Co Ltd	Carcinoma, Pancreatic Ductal; Pancreatic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
Linavonkibart	SRK-181; SRT-BETA-1-AB3	Phase 1 Clinical	Scholar Rock Inc	Neoplasms	Details
Charis-1000	Charis-1000; C 1K; C1K	Phase 1 Clinical	Ensol Biosciences Inc	Breast Neoplasms	Details
HLX-6018	HLX-6018; HLX6018	Phase 1 Clinical		Idiopathic Pulmonary Fibrosis	Details
RO7496353	RO7496353; RO-7496353; SOF 10; RG6440; RG-6440	Phase 1 Clinical	Genentech Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Solid tumours; Stomach Neoplasms	Details
JYB-1907	JYB-1907	Phase 1 Clinical	Jiangxi Jemincare Group Co Ltd	Solid tumours	Details
STP-707	STP-707; STP707	Phase 1 Clinical	Sirnaomics Biopharmaceuticals (Suzhou) Co Ltd	Cholangitis, Sclerosing; Liver Cirrhosis; Liver Neoplasms; Pancreatic Neoplasms; Pulmonary Fibrosis; Solid tumours	Details
PXS-64	PXS-64	Phase 1 Clinical	Syntara Ltd	Multiple Sclerosis	Details
BMS-986416	BMS-986416; AVID-200 DP; AVID-200	Phase 1 Clinical	Formation Biologics Corp	Polycythemia Vera; Primary Myelofibrosis; Scleroderma, Diffuse; Solid tumours; Thrombocythemia, Essential	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Tonogenchoncel-L	TG-C	Approved	Tissuegene	Invossa-K, Invossa	South Korea	Osteoarthritis	null	2017-07-01	Intervertebral Disc Degeneration; Osteoarthritis; Osteoarthritis, Knee	Details

Avis sur les produits

1***22019-10-12
3Mettre un like
Human TGF-Beta 1 / TGFB1 Protein, Tag Free
The TGFb1 protein was used as the negative comparing group in T-cell suppression experiments. The protein has a good bioactivity at suppressing T-cells by significantly inhibiting the proliferation of T-cells stimulated by anti-CD3. The repeatability and stability of the experiment was pretty good.