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TNF-beta
TNF-beta Overview
| English Name | Tumor necrosis factor β | Approved Drugs | 18 |
| Drugs in Clinical Trials | 6 | Target Synonym | TNF Superfamily Member 1，TNLG1E，LT，Lymphotoxin-alpha，TNFSF1，Tumor Necrosis Factor Ligand Superfamily Member 1，Tumor Necrosis Factor Beta，LT-alpha，LTA#TNFB，LTA，Lymphotoxin Alpha，TNF-Beta，TNFB，Lymphotoxin Alpha (TNF Superfamily， Member 1)，Tumor Necrosis Factor Ligand 1E，Truncated Lymphotoxin Alpha，TNF Superfamily， Member 1 |
| Highest Development Stage | Approved | ||
| English Name | Tumor necrosis factor β |
| Target Synonym | TNF Superfamily Member 1，TNLG1E，LT，Lymphotoxin-alpha，TNFSF1，Tumor Necrosis Factor Ligand Superfamily Member 1，Tumor Necrosis Factor Beta，LT-alpha，LTA#TNFB，LTA，Lymphotoxin Alpha，TNF-Beta，TNFB，Lymphotoxin Alpha (TNF Superfamily， Member 1)，Tumor Necrosis Factor Ligand 1E，Truncated Lymphotoxin Alpha，TNF Superfamily， Member 1 |
| Approved Drugs | 18 |
| Drugs in Clinical Trials | 6 |
| Highest Development Stage | Approved |
TNF-beta Product List
- Product Category
Protein (2)
- Product Status
Launched (2)
- Species
Human (2)
- Tag
His Tag (1)Fc Tag (1)
- Conjugate
Unconjugated (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
TNB-H5263 |  Human | HEK293 | Human TNF-beta / Lymphotoxin-alpha Protein, Fc Tag (MALS verified) |  |  |  |
TNB-H52H3 | Human | HEK293 | Human TNF-beta / Lymphotoxin-alpha Protein, His Tag (MALS verified) |  | | |
Total: 2
- 1
TNF-beta Background
TNF-beta is also known as Lymphotoxin-alpha (LT-alpha or LTA), Tumor necrosis factor ligand superfamily member 1 (TNFSF1), which belongs to the tumor necrosis factor family. TNF-beta can form homotrimer with itself or form heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. The homotrimer of TNF-beta is secreted and the heterotrimer is membrane-associated. The homotrimeric form of NF-beta binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR.
TNF-beta Synonyms
LTA,DAMA-25N12,13-004,LT,TNFB,TNFSF1,LT-alpha,TNF-beta
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Etanercept biosimilar (Clover Biopharmaceuticals) | SCB-808 | Phase 3 Clinical | Clover Biopharmaceuticals Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Thrombocytopenia | Details |
| Etanercept Biosimilar (Mabxience Holdings) | MB04; MB-04 | Phase 3 Clinical | Mabxience Holdings SL | Arthritis, Rheumatoid; Autoimmune Diseases | Details |
| Etanercept biosimilar (Suzhou Genemen Biotech) | BF-02; GM-02 | Phase 1 Clinical | Suzhou Genemen Biotech Co Ltd | Spondylitis, Ankylosing | Details |
| Etanercept biosimilar (Shilpa Biologicals) | SBDM-01 | Phase 1 Clinical | Shilpa Biologicals Pvt Ltd | Arthritis, Psoriatic; Arthritis, Rheumatoid; Plaque psoriasis; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing | Details |
| Etanercept (Neurokine Pharmaceuticals) | NP-1; NK-001 | Clinical | Pivot Pharmaceuticals | Cognition Disorders | Details |
| Etanercept biosimilar (Bio Sidus S.A) | Clinical | Biosidus | Arthritis, Rheumatoid; Autoimmune Diseases | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Etanercept biosimilar (Hanwha Chemical) | HD-203; MK-8953 | Approved | Hanwha Chemical | Davictrel | Arthritis, Psoriatic; Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing | Details | ||||
| Etanercept biosimilar (AryoGen Biopharma) | Approved | Aryogen Biopharma | Altebrel | Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing | Details | |||||
| Etanercept biosimilar (Nanogen Biopharmaceutical) | Approved | Nanogen Biopharmaceutical Co | Nanercept | Vietnam | Psoriasis; Arthritis, Rheumatoid | Nanogen Biopharmaceutical Co | 2019-01-01 | Arthritis, Rheumatoid; Psoriasis | Details | |
| Etanercept biosimilar (Mochida) | LBEC-0101 | Approved | Mochda Pharmaceutical Co Ltd | Japan | Arthritis, Juvenile; Arthritis, Rheumatoid | null | 2018-01-19 | Arthritis, Juvenile; Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (PROBIOMED) | Approved | Probiomed | Infinitam | Mexico | Arthritis, Rheumatoid | Probiomed | 2014-01-01 | Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (Sandoz) | GP-2015 | Approved | Clariant Produkte (Schweiz) Ag | Erelzi | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Sandoz | 2016-08-30 | Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Plaque psoriasis; Psoriasis; Spondylitis, Ankylosing | Details |
| Etanercept biosimilar (Amega Biotech) | Approved | Amega Biotech | Enerceptan | Argentina | Arthritis, Rheumatoid | Amega Biotech | 2012-01-01 | Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (Intas Biopharmaceuticals) | Approved | Intas Biopharmaceuticals | Intacept | India | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Intas Biopharmaceuticals | 2015-03-01 | Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing | Details | |
| Etanercept biosimilar (AXXO) | TNF-a-Fc | Approved | Axxo | Russian Federation | Arthritis, Rheumatoid | Axxo | 2013-01-01 | Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (Mylan) | YLB-113 | Approved | Lupin Ltd, Mylan Nv | Nepexto | EU | Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Juvenile; Arthritis, Rheumatoid; Plaque psoriasis | Biosimilar Collaborations Ireland Ltd | 2020-05-20 | Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Plaque psoriasis; Spondylarthropathies; Spondylitis, Ankylosing | Details |
| Etanercept biosimilar (Sunshine Guojian) | 301S | Approved | Jiangsu Xipula Pharmaceutical Co Ltd, Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | Yisaipu, 益赛普, Etanar, Etacept | Mainland China | Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | 2005-06-20 | Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing | Details |
| Opinercept | E-11; ENIA-11 | Approved | Mycenax Biotech Inc, TSH Biopharm Corp Ltd | TuNEX | Taiwan | Arthritis, Rheumatoid | null | 2017-01-01 | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details |
| Etanercept biosimilar (Reliance Life Sciences) | Approved | Reliance Life Sciences | Arthritis, Rheumatoid | Details | ||||||
| Etanercept biosimilar (Shanghai Celgen) | Approved | Shanghai Celgen Bio-Pharmaceutical Co Ltd | 强克 | Mainland China | Spondylitis, Ankylosing | Shanghai Celgen Bio-Pharmaceutical Co Ltd | 2011-04-01 | Arthritis, Rheumatoid; Plaque psoriasis; Psoriasis; Spondylitis, Ankylosing | Details | |
| Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) | Approved | Hisun-Pfizer | AnBaiNuo, 安佰诺 | Mainland China | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Wyeth Europa Ltd | 2010-02-26 | Arthritis, Psoriatic; Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing | Details | |
| Etanercept biosimilar (Qilu Pharmaceutical) | QL-0902 | Approved | Qilu Pharmaceutical Co Ltd | Mainland China | Qilu Pharmaceutical Co Ltd | 2023-12-19 | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details | ||
| Etanercept biosimilar (Samsung Bioepis) | SB-4 | Approved | Samsung Bioepis Co Ltd | Eticovo, Benepali | EU | Arthritis, Psoriatic; Arthritis, Rheumatoid; Plaque psoriasis; Spondylitis, Ankylosing | Samsung Bioepis Nl Bv | 2016-01-13 | Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Plaque psoriasis; Psoriasis; Spondylitis, Ankylosing | Details |
| Etanercept | TNR-001 | Approved | Amgen Inc, Pfizer Inc | Lifmior, 恩利, Enbrel | EU | Arthritis, Juvenile; Plaque psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Psoriatic | Pfizer Europe Ma Eeig | 2000-02-02 | Acute Lung Injury; Alzheimer Disease; Anorexia; Arthritis; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Asthma; Bone Neoplasms; Bronchiolitis Obliterans; Cachexia; Chronic Urticaria; Diabetes Mellitus, Type 1; Fanconi Anemia; Graft vs Host Disease; Granulomatosis with Polyangiitis; Hidradenitis Suppurativa; HIV Infections; Inflammation; Kidney Failure, Chronic; Leukemia; Lichen Planus; Lung Neoplasms; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid; Metabolic Syndrome; Myositis, Inclusion Body; Neoplasm Metastasis; Non-radiographic axial spondyloarthritis; Obesity; Plaque psoriasis; Prostatic Neoplasms; Psoriasis; Pulmonary Fibrosis; Rejection of lung transplantation; Respiratory Distress Syndrome, Adult; Sjogren's Syndrome; Solid tumours; Spondylarthritis; Spondylitis, Ankylosing; Stomatitis; Synovitis; Temporomandibular Joint Disorders; Tinnitus; Uveitis; Vasculitis; Vitiligo | Details |
- Overview
- Product List
- Marketed Drug Information
- Clinical Drug Information
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