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TOP2A

TOP2A

TOP2A Informations sur la molécule

Molecule Name
Topoisomerase (DNA) II alpha
Alias de la molécule
TOP2A,TOP2,DNA topoisomerase 2-alpha,DNA topoisomerase II,alpha isozyme
Drug Development Progress
Nombre de médicaments cliniques1
Nombre de médicaments commercialisés1
Phase de R&D la plus avancéeApproved
Alias de la cible
EC:5.6.2.2，EC 5.6.2.2，TOP2A，DNA topoisomerase 2-alpha，DNA topoisomerase II， alpha isozyme，DNA Topoisomerase II Alpha，Topoisomerase (DNA) II Alpha 170kDa，TOP2，DNA Topoisomerase (ATP-Hydrolyzing)，DNA Topoisomerase II， 170 KD，EC 5.99.1.3，TP2A，DNA Gyrase
Contexte de la molécule
DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.

TOP2A Liste de produits

Species
  • Human（1）
Tag
  • Tag Free（1）
Host
  • E. coli（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • No（1）
MoleculeCat. No.Product NameEspèceHostStructurePurityActivitySize&PriceAdd to Cart
TOP2A
TOA-H5117
Human TOP2A / TOP2 Protein, Tag Free
Human
E. coli
SDS-PAGE

$310.00

20ug
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Informations sur les médicaments cliniques

Nom anglaisCode de recherchePhase de R&DEntrepriseIndicationEssai clinique
Novobiocin SodiumPhase 1 Clinical
Bacterial Infections; Neoplasms; Solid tumours
Details

Informations sur les médicaments commercialisés

Nom anglaisCode de recherchePhase de R&DEntreprisePlus ancien nom de marquePays d'approbation le plus ancienIndication la plus ancienneSociété d'approbation la plus ancienneDate d'approbation la plus ancienneIndicationEssai clinique
Etoposide phosphateBMY-40481ApprovedBristol-Myers Squibb CompanyEtopophosUnited StatesLymphoma, Non-Hodgkin; Multiple Myeloma; Testicular Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hodgkin Disease; Small Cell Lung CarcinomaCheplapharm Arzneimittel Gmbh1996-05-17
Adrenocortical Carcinoma; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; CNS Embryonal Tumor; Germinoma; Hodgkin Disease; Kidney Neoplasms; Leukemia; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neoplasms, Gonadal Tissue; Neoplasms, Plasma Cell; Neuroblastoma; Neutropenia; Ovarian Neoplasms; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Sarcoma, Ewing; Small Cell Lung Carcinoma; Solid tumours; Testicular Neoplasms; Thrombocytopenia; Uterine Cervical Neoplasms
Details
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