TRAIL R1

TRAIL R1 Informations sur la molécule

Nom anglais	Tumor necrosis factor receptor superfamily member 10A	Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	3	Alias de la cible	TRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
Phase de R&D la plus avancée	Approved

Nom anglais	Tumor necrosis factor receptor superfamily member 10A
Alias de la cible	TRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
Nombre de médicaments commercialisés	1
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Approved

TRAIL R1 Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Human (2)
Étiquette
His Tag (1)Fc Tag (1)
Marqueur
Unconjugated (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
TR1-H5228	Human	HEK293	Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag				Ajouter au panier
TR1-H5254	Human	HEK293	Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag				Ajouter au panier

Quantité totale2

TRAIL R1Contexte de la molécule

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

TRAIL R1Alias de la molécule

TNFRSF10A,TRAIL-R1,CD261,APO2,DR4

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Dulanermin (Shanghai GeBaiDe)		Phase 3 Clinical	Shanghai Gebaide Biotechnology Co Ltd	Carcinoma, Non-Small-Cell Lung	Details
Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (Shenzhen Xinpeng Biotech)		Phase 3 Clinical	Shenzhen Sinobioway Xinpeng Biomedicine Co Ltd	Neoplasms	Details
HLX56	HLX56; HLX-56	Phase 1 Clinical		Solid tumours	Details

Informations sur les médicaments commercialisés

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Plus ancien nom de marque	Pays d'approbation le plus ancien	Indication la plus ancienne	Société d'approbation la plus ancienne	Date d'approbation la plus ancienne	Indication	Essai clinique
Aponermin		Approved	Beijing Shadong Biotech Co Ltd	沙艾特, Shaite	Mainland China	Multiple Myeloma	Wuhan Hiteck Biological Pharma Co Ltd	2023-11-02	Multiple Myeloma	Details

Avis sur les produits

1***22019-09-30
0Mettre un like
Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
I purchased TNFRSF10A to measure the binding. I tested the purity first. From the results of the SEC (see attachment), you can see the purity is pretty good, 94.8%.