UBE1 Overview
Molecule Name
Ubiquitin-like modifier-activating enzyme 1
Synonyms
A1S9T and BN75 temperature sensitivity complementing,A1S9T,A1ST,AMCX1,GXP1,MGC4781,POC20 centriolar protein homolog,POC20,Protein A1S9,SMAX2,UBA1,UBA1, ubiquitin-activating enzyme E1 homolog A,UBA1A,UBE1,UBE1A1S9,UBE1X,ubiquitin-activating enzyme E1 (A1S9
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs0
Highest Development StagePhase 1 Clinical
Target Synonym
EC:6.2.1.45，UBE1，Ubiquitin-Activating Enzyme E1 (A1S9T And BN75 Temperature Sensitivity Complementing)，UBA1， Ubiquitin-Activating Enzyme E1 Homolog (Yeast)，POC20 Centriolar Protein Homolog (Chlamydomonas)，Ubiquitin-Like Modifier Activating Enzyme 1，Testicular Secretory Protein Li 63，EC 6.2.1.45，CFAP124，AMCX1，POC20，SMAX2，UBA1A，UBE1X，A1S9，A1ST，GXP1，Ubiquitin-activating enzyme E1，Protein A1S9，A1S9T，Ubiquitin-like modifier-activating enzyme 1，UBA1，Ubiquitin Like Modifier Activating Enzyme 1，A1S9T And BN75 Temperature Sensitivity Complementing，UBA1， Ubiquitin-Activating Enzyme E1 Homolog A，POC20 Centriolar Protein Homolog
Background
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
UBE1 Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| TAK-243 | TAK-243; MLN-7243 | Phase 1 Clinical | Takeda Pharmaceutical Co Ltd | Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Solid tumours | Details |