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Biotinylated Monoclonal Anti-DXD Antibody, Mouse IgG1 (AM807)

  • Antibody Internalization Detection Reagent (IGG-PZF2001) monitors endocytosis in live cells
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Prix
Availability
Qté
DXD-BVM807-25ug
$705.00
In Stock - Delivery in 2-3 business days
DXD-BVM807-200ug
$4920.00
In Stock - Delivery in 2-3 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Source

    Chimeric Biotinylated Monoclonal Anti-DXD Antibody, Mouse IgG1 (AM807) is recombinantly expressed in HEK293. It consists of mouse variable regions genetically fused to mouse IgG1 constant domains.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    AM807

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Immunogen

    DXD

  • Conjugate

    Biotinylated

  • Specificity

    Specifically recognizes the target-DXD.

  • Application

    Application
    Recommended Use / Performance
    ELISA
    1:100-1:1000
  • Purification

    Protein A purified.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Affichage des données

  • Bioactivity-ELISA

     DXD ELISA

    Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 1 μg/mL, add Trastuzumab Deruxtecan in the 100% Human Serum and then add Biotinylated Monoclonal Anti-DXD Antibody, Mouse IgG1 (AM807) (Cat. No. DXD-BVM807) at 0.05 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

    Protocol
  •  DXD ELISA

    Immobilized Trastuzumab Deruxtecan at 1 μg/mL (100 μL/well) can bind Biotinylated Monoclonal Anti-DXD Antibody, Mouse IgG1 (AM807) (Cat. No. DXD-BVM807) with a linear range of 0.5-8 ng/mL (Routinely tested).

    Protocol

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FAQ

  • product

    Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?

    In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.


    Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.


    To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.


    To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.


    Supporting Document


Introduction de fond

DXD (Exatecan derivative) is a potent DNA topoisomerase I inhibitor and is widely used as a cytotoxic payload of antibody-drug conjugates (ADCs) for the treatment of multiple cancers. Anti-DXD antibody is a mouse monoclonal antibody. This antibody has been validated for use in PK, PD, immunoassays, and ELISA.

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