ACE2 Overview
Molecule Name
Angiotensin-converting enzyme 2
Synonyms
ACE-2,ACEH,ACE2
Drug Development Progress
Drugs in Clinical Trials7
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Angiotensin-converting enzyme homolog，Metalloprotease MPROT15，ACEH，Angiotensin I Converting Enzyme 2，Angiotensin-converting enzyme-related carboxypeptidase，Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2，Peptidyl-Dipeptidase A，ACE-related carboxypeptidase
Background
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
ACE2 Product List
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- X***n2021-09-01We have been using this antigen since early 2020. We internal QC showed very high quality, in terms of purity, solubility, sequence correctness, stability, etc. This reagent jump started our program. We have been using it in antibody screening funnel as well as blocking assays. It behaves very well in ELISA and SPR. I am also impressed by ACRO Bio's speedy logistic and technical support communications.