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Alpha-synuclein

Alpha-synuclein

Alpha-synuclein Overview

Molecule Name
Synuclein alpha
Synonyms
NACP, PARK1, PARK4, PD1
Drug Development Progress
Drugs in Clinical Trials25
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
Truncated Alpha Synuclein，Α-Synuclein，PARK1，SNCA，Synuclein Alpha，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor，Non A-Beta Component Of AD Amyloid，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，alpha-Synuclein
Background
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Alpha-synuclein Product List

Species
  • Human（14）
  • Mouse（2）
  • Cynomolgus（1）
Tag
  • His Tag（8）
  • Tag Free（7）
  • Fc Tag（1）
  • His Tag & Avi Tag（1）
Host
  • E. coli（16）
  • HEK293（1）
Conjugate
  • Unconjugated（12）
  • AF488 Labeled（2）
  • AF647 Labeled（2）
  • Biotin-labeled（1）
Grade
  • RUO（17）
Low Endotoxin
  • Yes（4）
  • No（13）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
Alpha-synuclein
HOTAIDD‑Ready
ALN-H5253
Human Alpha-Synuclein Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$165.00

200ug
Alpha-synuclein
HOTAIDD‑Ready
ALN-H5114
Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free
Human
E. coli
SDS-PAGE
CELL BASE

$360.00

100ug
Alpha-synuclein
HOTAIDD‑Ready
ALN-H5115
Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free
Human
E. coli
SDS-PAGE
CELL BASEThT

$360.00

100ug
Alpha-synuclein
HOTAvitagAIDD‑Ready
ALN-H82H8
Biotinylated Human Alpha-Synuclein Protein, His,Avitag™ (MALS verified)
Human
E. coli
MALSSDS-PAGE
ELISA

$360.00

25ug
Alpha-synuclein
HOTAIDD‑Ready
ALN-H5214
Human Alpha-Synuclein Protein, Tag Free, low endotoxin (MALS verified)
Human
E. coli
MALSSDS-PAGE
ELISA

$305.00

200ug
Alpha-synuclein
HOTAIDD‑Ready
ALN-H52H8
Human Alpha-Synuclein Protein, His Tag, low endotoxin
Human
E. coli
SDS-PAGE

$165.00

200ug
Alpha-synuclein
AIDD‑Ready
ALN-C52H5
Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)
Cynomolgus
E. coli
MALSSDS-PAGE
ELISA

$185.00

200ug
Alpha-synuclein
AIDD‑Ready
ALN-H5116
Human Alpha-Synuclein (A53T) Protein, Tag Free, low endotoxin (MALS verified)
Human
E. coli
MALSSDS-PAGE
ELISA

$290.00

200ug
Alpha-synuclein
AIDD‑Ready
ALN-H5117
Human Alpha-Synuclein (E46K) Protein, Tag Free
Human
E. coli
SDS-PAGE
ELISA

$290.00

200ug
Alpha-synuclein
AIDD‑Ready
ALN-H51H4
Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag
Human
E. coli
SDS-PAGE
CELL BASEThT

$350.00

100ug
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FAQ

How can Alpha-Synuclein proteins be used in binding and kinetic assays?

Alpha-synuclein proteins can be used to characterize molecular interactions with antibodies, receptors, or other binding partners using techniques such as SPR and BLI. Site-specific biotinylated Alpha-synuclein provides a defined attachment strategy for streptavidin-based immobilization, helping support consistent assay configuration and characterization of binding affinity and kinetics.

How can fluorescent-labeled Alpha-Synuclein be used to study protein internalization and seeding?

Fluorescent-labeled Alpha-synuclein, including AF488- and AF647-labeled proteins, enables researchers to monitor Alpha-synuclein uptake and intracellular localization in cell-based experiments. Fluorescence microscopy and flow cytometry can be used to quantify internalization and examine intracellular trafficking. Fluorescently labeled PFFs can also help distinguish exogenous seeds from endogenous Alpha-synuclein during seeding studies.

What are Alpha-Synuclein pre-formed fibrils (PFFs) used for?

Alpha-synuclein pre-formed fibrils (PFFs) are widely used to model pathological Alpha-synuclein aggregation and seeding. When introduced into cells or animal models, PFFs can be internalized and act as seeds that recruit endogenous Alpha-synuclein into intracellular aggregates. They are therefore useful for studying Alpha-synuclein aggregation, propagation, pathology mechanisms, and therapeutic interventions.

Why is Alpha-Synuclein associated with Parkinson’s disease?

Alpha-synuclein is strongly associated with Parkinson’s disease because abnormal Alpha-synuclein can misfold and form oligomers, fibrils, and other pathological assemblies found in Lewy bodies. These pathological species can disrupt synaptic and cellular functions and contribute to neuronal dysfunction and neurodegeneration. Alpha-synuclein aggregation is also a defining feature of several other synucleinopathies.

What is Alpha-Synuclein, and what does it do in neurons?

Alpha-synuclein is a presynaptic neuronal protein encoded by the SNCA gene. It is involved in synaptic vesicle trafficking, membrane interactions, and neurotransmitter release, and can contribute to SNARE complex assembly at presynaptic terminals. Although its physiological functions are not fully understood, Alpha-synuclein is considered important for maintaining normal synaptic activity.
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Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
BuntanetapANVS-405; ANVS-401Phase 3 ClinicalRaptor Pharmaceutical
Alzheimer Disease; Chronic Traumatic Encephalopathy; Cognitive Dysfunction; Down Syndrome; Frontotemporal Dementia; Parkinson Disease
Details
AmlenetugLu AF-82422; Lu AF82422; Lu-AF82422Phase 3 ClinicalGenmab A/S, H. Lundbeck A/S
Multiple System Atrophy; Parkinson Disease
Details
PrasinezumabPRX-002; RG-7935; NEOD-002; RO-7046015Phase 3 ClinicalProthena
Parkinson Disease
Details
KenterinENT-01; kenterin; Enterin-01Phase 2 ClinicalEnterin Inc
Constipation; Dementia; Parkinson Disease
Details
PBT-434PBT-434; ATH-434Phase 2 ClinicalPrana Biotechnology Ltd
Multiple System Atrophy
Details
MT101-5MT101-5Phase 2 ClinicalMthera Pharma Co Ltd
Parkinson Disease
Details
AMDX-2011PAMDX2011P; AMDX-2011PPhase 2 ClinicalAmydis Inc
Alzheimer Disease; Amyotrophic Lateral Sclerosis; Cerebral Amyloid Angiopathy; Glaucoma, Open-Angle; Parkinson Disease
Details
ACI-7104ACI-7104.056; ACI-7104Phase 2 ClinicalAc Immune Sa
Parkinson Disease
Details
MinzasolminUCB-1332; NPT200-11; DLX-313; DLX313; UCB-0599Phase 2 ClinicalNeuropore Therapies Inc
Parkinson Disease
Details
ExidavnemabPD-0805; BAN-0805; BBV-0805; ABBV-0805; PR-1808164Phase 2 ClinicalBioarctic Ab
Multiple System Atrophy; Parkinson Disease
Details
EmrusolminTEV-56286; TEV-'286; Anle-138b; TEV-286Phase 2 ClinicalLudwig-Maximilians-University, Max Planck Institute for Biophysical Chemistry
Multiple System Atrophy; Parkinson Disease
Details
ION-464BIIB-101; IONIS-BIIB6 Rx; ION-464Phase 1 ClinicalIonis Pharmaceuticals Inc
Multiple System Atrophy
Details
UB-312UB-312Phase 1 ClinicalUnited Neuroscience Ltd
Multiple System Atrophy; Parkinson Disease; Parkinsonian Disorders
Details
SAR-446159SAR-446159; ABL-301Phase 1 ClinicalAbl Bio Inc
Parkinson Disease
Details
SST-001SST001; SST-001; 18F-FD4Phase 1 ClinicalSynuSight Biotech (Shanghai) Co Ltd
Diagnostic agents; Lewy Body Disease; Multiple System Atrophy; Parkinson Disease; Synucleinopathies
Details
18F-CP6A18F-CP6APhase 1 ClinicalShenzhen Braegen Pharmaceutical Co Ltd
Synucleinopathies
Details
AB-16AB-16Phase 1 ClinicalAutotac Bio Inc
Parkinson Disease
Details
ACI-12589ACI-12589; a-syn-PET tracer (AC Immune); [18F]MNI-1216; [18F]ACI-12589Phase 1 ClinicalAc Immune Sa, Biogen Inc, Invicro Llc
Lewy Body Disease; Multiple System Atrophy; Parkinson Disease; Synucleinopathies
Details
PK-081PK081; PK-081Phase 1 ClinicalPharmaKure Ltd
Parkinson Disease
Details
[11C]SY-08[11C]SY-08; [11C]SY08Phase 1 ClinicalMassachusetts General Hospital
Lewy Body Disease; Multiple System Atrophy; Parkinson Disease
Details
SNP201SNP201; SNP-201Phase 1 ClinicalSciNeuro Pharmaceuticals
Parkinson Disease
Details
[18F]UCB-2897UCB-2897; [18F]UCB-2897Phase 1 ClinicalInvicro Llc
Multiple System Atrophy; Parkinson Disease
Details
ACI-3847ACI-3847; 18F-ACI-3847Phase 1 ClinicalAc Immune Sa, Biogen Inc
Neurodegenerative Diseases; Parkinson Disease
Details
UCB-7853UCB-7853Phase 1 ClinicalUcb Biopharma Srl
Parkinson Disease
Details
Syneuro (Indus Biotech)ClinicalIndus Biotech Pvt Ltd
Parkinson Disease
Details
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