DDR1

DDR1 Informations sur la molécule

Nom anglais	Discoidin domain receptor 1	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5	Alias de la cible	Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Discoidin domain receptor 1
Alias de la cible	Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5
Phase de R&D la plus avancée	Phase 2 Clinical

DDR1 Liste de produits

Attribut
Protein (3)
Bibliothèque de produits
En ligne (3)
Espèces
Human (2)Mouse (1)
Étiquette
Fc Tag (2)His Tag & Avi Tag (1)
Marqueur
Unconjugated (2)Biotin-labeled (1)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT DD1-H82E9	Human	HEK293	Biotinylated Human DDR1 Protein, His,Avitag™ (MALS & BLI verified)	Ajouter au panier
DD1-H5258	Human	HEK293	Human DDR1 Protein, Fc Tag (BLI verified)	Ajouter au panier
DD1-M5259	Mouse	HEK293	Mouse DDR1 Protein, Fc Tag	Ajouter au panier

Quantité totale3

Demande de produit

DDR1Contexte de la molécule

Discoidin domain receptor 1 (DDR1) is a member of DDRs, which are members of the receptor tyrosine kinase (RTK). Upon collagen binding, DDR1 undergoes tyrosine autophosphorylation, which consequently triggers downstream genetic and cellular pathways and plays critical roles in the regulation of cellular morphogenesis, differentiation, proliferation, adhesion, migration, and invasion. Research shows that DDR1 is closely related to various human diseases including cancer, fibrosis, atherosclerosis, and other inflammatory disorders. New generation DDR1 inhibitors targeting the allosteric sites outside of the canonical ATP-binding pocket or extracellular domain (allosteric inhibitors) may offer a new opportunity for selective DDR1 inhibition therapy development.

DDR1Alias de la molécule

CD167a

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	Details
Ensavatatug	PRTH-101	Phase 1 Clinical	Parthenon Therapeutics Inc, The George Washington University Milken Institute School Of Public Health (Gwu)	Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours	Details
ICP-033	ICP-033	Phase 1 Clinical	Beijing Innocare Pharma Tech Co Ltd	Solid tumours	Details
AVI-4015	AVI-4015	Phase 1 Clinical	Avixgen	Dry Eye Syndromes	Details
AGX-0073	AGX-0073	Phase 1 Clinical	Shanghai Aojian Biological Technology Co Ltd	Solid tumours	Details