Frizzled-7

Frizzled-7 Informations sur la molécule

Nom anglais	Frizzled-7	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1	Alias de la cible	FZD7，Frizzled-7，hFz7，Fz-7，Frizzled Class Receptor 7，Frizzled 7， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 7，FzE3，Frizzled， Drosophila， Homolog Of， 7，Frizzled (Drosophila) Homolog 7，Frizzled Homolog 7，Frizzled Homolog 7 (Drosophila)
Phase de R&D la plus avancée	Phase 1 Clinical

Nom anglais	Frizzled-7
Alias de la cible	FZD7，Frizzled-7，hFz7，Fz-7，Frizzled Class Receptor 7，Frizzled 7， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 7，FzE3，Frizzled， Drosophila， Homolog Of， 7，Frizzled (Drosophila) Homolog 7，Frizzled Homolog 7，Frizzled Homolog 7 (Drosophila)
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	1
Phase de R&D la plus avancée	Phase 1 Clinical

Frizzled-7 Liste de produits

Attribut
Protein (2)
Bibliothèque de produits
En ligne (2)
Espèces
Human (2)
Étiquette
Fc Tag (1)His Tag (1)
Marqueur
Unconjugated (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Structure protéique	Pureté	Caractéristiques	Pré-commande/Commande
FZ7-H5258	Human	HEK293	Human Frizzled-7 / FZD7 Protein, Fc Tag				Ajouter au panier
FZ7-H52H9	Human	HEK293	Human Frizzled-7 / FZD7 Protein, His Tag				Ajouter au panier

Quantité totale2

Frizzled-7Contexte de la molécule

Frizzled-7 (FZD7) is also known as FzE3, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD7 contains one FZ (frizzled) domain. FZD7 is receptor for Wnt proteins. FZD7 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD7 interacts with MAGI3 and DVL1.

Frizzled-7Alias de la molécule

FZD7,Frizzled-7,FzE3,Fz-7,hFz7

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
Vantictumab	OMP-18R5; anti-Fzd7	Phase 1 Clinical	Bayer AG, Oncomed Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Osteopetrosis; Pancreatic Neoplasms; Solid tumours	Details