Klotho beta

Klotho beta Informations sur la molécule

Nom anglais	Klotho beta	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3	Alias de la cible	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Klotho beta
Alias de la cible	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	3
Phase de R&D la plus avancée	Phase 2 Clinical

Klotho beta Liste de produits

Attribut
Protein (7)
Bibliothèque de produits
En ligne (7)
Espèces
Mouse (2)Cynomolgus / Rhesus macaque (1)Rat (1)Human (2)Rhesus macaque (1)
Étiquette
His Tag (7)
Marqueur
Unconjugated (5)Biotin-labeled (2)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT KLB-H52H4	Human	HEK293	Human Klotho beta / KLB Protein, His Tag	Ajouter au panier
HOT KLB-M52H7	Mouse	HEK293	Mouse Klotho beta / KLB Protein, His Tag	Ajouter au panier
HOT KLB-R52H8	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag	Ajouter au panier
KLB-H82H3	Human	HEK293	Biotinylated Human Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)	Ajouter au panier
KLB-M52H3	Mouse	HEK293	Biotinylated Mouse Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling) (HPLC verified)	Ajouter au panier
KLB-R52H6	Rat	HEK293	Rat Klotho beta / KLB Protein, His Tag	Ajouter au panier
KLB-R82H3	Rhesus macaque	HEK293	Biotinylated Rhesus macaque Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)	Ajouter au panier

Quantité totale7

Klotho betaContexte de la molécule

KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.

Klotho betaAlias de la molécule

betaKlotho,beta-klotho,BKL,KLB,klotho beta like,klotho beta-like protein

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
NGM-313	NGM-313; MK-3655	Phase 2 Clinical	NGM Biopharmaceuticals Inc	Hepatitis; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity	Details
JMT-202	JMT202; JMT-202	Phase 2 Clinical	Shanghai Jmt-Bio Inc	Hypertriglyceridemia	Details
DR-10624	DR-10624; DR10624	Phase 2 Clinical	Zhejiang Doer Biologics Corp	Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight	Details