LILRB1

LILRB1 Informations sur la molécule

Nom anglais	Leukocyte immunoglobulin-like receptor B1	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	6	Alias de la cible	Leukocyte Immunoglobulin Like Receptor B1，LIR-1，MIR-7，ILT2，LIR1，Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 Soluble Isoform，PIR-B，Leukocyte immunoglobulin-like receptor 1，MIR7，PIRB，CD85j，Immunoglobulin-like transcript 2，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 1，Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1，Monocyte/Macrophage Immunoglobulin-Like Receptor 7，CD85 Antigen-Like Family Member J，Myeloid Inhibitory Receptor 7，Leucocyte Ig-Like Receptor B1，ILT-2，CD85j Antigen，Ig-Like Transcript 2
Phase de R&D la plus avancée	Phase 2 Clinical

Nom anglais	Leukocyte immunoglobulin-like receptor B1
Alias de la cible	Leukocyte Immunoglobulin Like Receptor B1，LIR-1，MIR-7，ILT2，LIR1，Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 Soluble Isoform，PIR-B，Leukocyte immunoglobulin-like receptor 1，MIR7，PIRB，CD85j，Immunoglobulin-like transcript 2，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 1，Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1，Monocyte/Macrophage Immunoglobulin-Like Receptor 7，CD85 Antigen-Like Family Member J，Myeloid Inhibitory Receptor 7，Leucocyte Ig-Like Receptor B1，ILT-2，CD85j Antigen，Ig-Like Transcript 2
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	6
Phase de R&D la plus avancée	Phase 2 Clinical

LILRB1 Liste de produits

Attribut
Protein (7)
Bibliothèque de produits
En ligne (7)
Espèces
Human (6)Cynomolgus (1)
Étiquette
Fc Tag (1)Fc Tag & Avi Tag (2)His Tag (3)His Tag & Avi Tag (1)
Marqueur
Unconjugated (4)Biotin-labeled (3)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
HOT CDJ-H52H4	Human	HEK293	Human LILRB1 / CD85j / ILT2 Protein, His Tag (MALS verified)	Ajouter au panier
HOT CDJ-H52H6	Human	HEK293	Human LILRB1 / CD85j / ILT2 (23-431) Protein, His Tag (MALS verified)	Ajouter au panier
HOT CDJ-H82E8	Human	HEK293	Biotinylated Human LILRB1 / CD85j / ILT2 Protein, His,Avitag™ (MALS verified)	Ajouter au panier
HOT CDJ-C52H3	Cynomolgus	HEK293	Cynomolgus LILRB1 / CD85j / ILT2 Protein, His Tag	Ajouter au panier
CDJ-H5252	Human	HEK293	Human LILRB1 / CD85j / ILT2 Protein, Fc Tag (MALS verified)	Ajouter au panier
CDJ-H82F7	Human	HEK293	Biotinylated Human LILRB1 / CD85j / ILT2 Protein, Fc,Avitag™	Ajouter au panier
CDJ-H82F9	Human	HEK293	Biotinylated Human LILRB1 / CD85j / ILT2 Protein, Fc,Avitag™ (MALS verified)	Ajouter au panier

Quantité totale7

LILRB1Contexte de la molécule

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB1Alias de la molécule

CD85J,LILRB1,CD85,ILT2,LIR1,MIR7

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
NGM-707	NGM-707	Phase 2 Clinical	Merck & Co, NGM Biopharmaceuticals Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Glioblastoma; Melanoma; Mesothelioma; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Uterine Cervical Neoplasms	Details
Zamristobart	BND-22; SAR-444881	Phase 2 Clinical	Biond Biologics Ltd	Neoplasms; Solid tumours	Details
IOS-1002	ios-H2	Phase 1 Clinical	ImmunOs Therapeutics AG	Hematologic Neoplasms; Solid tumours	Details
AK-150 (Akeso)	AK150; AK-150	Phase 1 Clinical		Solid tumours	Details
LB-LR1109	LB-LR1109; LR-19155; LR19155	Phase 1 Clinical	Lg Chemical Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Melanoma; Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
AGEN-1571	AGEN-1571	Phase 1 Clinical	Agenus Inc	Neoplasms; Solid tumours	Details

Avis sur les produits

M***n2025-04-24
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Biotinylated Human LILRB1 / CD85j / ILT2 Protein, Fc,Avitag™
This protein product from Acrobio Systems is high-quality and easy to use. The biotinylation via Avitag™ ensures consistent labeling, and the Fc tag provides good stability. It worked well in our binding assays, delivering reliable and reproducible results. Great option for researchers studying immune checkpoints or receptor-ligand interactions. Additionally, the protein was delivered quickly and arrived in excellent condition, with clear documentation and high purity confirmed by SDS-PAGE. It demonstrated strong and specific binding in flow cytometry and ELISA setups. The consistent performance across experiments made it a dependable tool in our studies. Highly recommended for immunology and cell biology applications where ligand-receptor interactions are key.
M***h2022-04-01
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Biotinylated Human LILRB1 / CD85j / ILT2 Protein, Fc,Avitag™
This sample was highly pure which was very helpful in selection campaigns to find specific molecules. We did our own QC on the sample to verify purity and it matched up perfectly with SDS-PAGE and SEC-MALS that is provided on the website. Shipping was quick to prevent delays in our project timelines. This sample was sent lyophilized and very easy to reconstitute for use.