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Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (UCHT1)

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Numéro de produit/spécification
Prix
Qté
CDE-M532-100ug
$35.00
CDE-M532-1mg (500ug X 2)
$310.00
CDE-M532-10mg (500ug X 20)
Demande
CDE-M532-100mg (500ug X 200)
Demande
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Source

    Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (UCHT1) is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    UCHT1

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Immunogen

    Purified Human CD3 Protein

  • Specificity

    This product is a specific antibody specifically reacts with CD3.

  • Application

    ELISA (Evaluation of levels of CD3 protein).

    Flow Cytometry (Detection the expression of CD3 on Human cells).

  • Isotype Control

    The isotype control is sold separately; please refer to Cat. No. DNP-M1A1 for product information.

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 24 months in lyophilized state;
    2. -70°C for 12 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Affichage des données

  • Bioactivity-FACS

     CD3 FACS

    2e5 of Jurkat cells were stained with 100 μL of 1 μg/mL of Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (UCHT1) (Cat. No. CDE-M532) and isotype control antibody respectively, washed and then followed by PE-anti mouse IgG1 antibody and analyzed with FACS (Routinely tested).

    Protocol
  • Bioactivity-ELISA

     CD3 ELISA

    Immobilized Human CD3E&CD3D Heterodimer Protein (Cat. No. CDD-H52Wa) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (UCHT1) (Cat. No. CDE-M532) with a linear range of 0.1-3 ng/mL (QC tested).

    Protocol

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Introduction de fond

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    T cell surface glycoprotein CD3

  • Catégorie:

  • Nombre de médicaments répertoriés:

    10 Détails

  • Nombre de médicaments cliniques:

    198 Détails

  • Étape de développement la plus élevée:

    Approved

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