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Background
Recombinant Monoclonal Anti-PD-1 Antibody, Mouse (2F3) is a PD-1 primary antibody for IHC application. Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Product Specifications
Host SpeciesMouseIsotypeMouse IgGClone2F3ApplicationIHC-PDilution Ratio1: 200 - 1: 1000FormLiquidClonalityMonoclonalReactivityHumanSynonymsPD1, CD279, PD-1, PDCD1Concentration0.9~1.1 mg/mlSpecificityReact with PD-1 protein on the membrane of target cell/tissuePurification TechProtein APreservationTris buffer, 1% BSAExperiment Protocol
Storage
Shipped at 4°C, Blue Ice. Store at +4°C for short term (1-2 weeks). Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot. The shelf life is 30 days from the date of opening.ACRO Quality Management System
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Sample Staining Data
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S238 at 1/500 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Programmed cell death protein 1
- Catégorie：
- Nombre de médicaments répertoriés：
22 Détails
- Nombre de médicaments cliniques：
193 Détails
- Étape de développement la plus élevée：
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