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Détails du produit
Synonyms
Activin receptor type IIA, ACTRIIA
Source
Human / Cynomolgus Activin RIIA Protein, His Tag (ACA-H5243) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 135 (Accession # P27037-1). In the region Ala 20 - Pro 135, the amino acid sequences of Human and Cynomolgus Activin RIIA are identical.
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 15.4 kDa. The protein migrates as 29-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Affichage des données
SDS-PAGE
Human / Cynomolgus Activin RIIA Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human / Cynomolgus Activin RIIA Protein, His Tag (Cat. No. ACA-H5243) is more than 95% and the molecular weight of this protein is around 18-28 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human / Cynomolgus Activin RIIA Protein, His Tag (Cat. No. ACA-H5243) at 1 μg/mL (100 μL/well) can bind Bimagrumab with a linear range of 0.05-1 ng/mL (Routinely tested).
Protocol
Bioactivity-SPR
Human / Cynomolgus Activin RIIA Protein, His Tag (Cat. No. ACA-H5243) immobilized on CM5 Chip can bind Human Activin A Protein, premium grade (Cat. No. ACA-H5314) with an affinity constant of 85.9 pM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
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Introduction de fond
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Activin receptor type-2A
- Catégorie：
- Nombre de médicaments répertoriés：
0 Détails
- Nombre de médicaments cliniques：
4 Détails
- Étape de développement la plus élevée：
Phase 2 Clinical
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