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Human Cadherin-17 / CDH17 Protein, His Tag, low endotoxin (Active)

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Numéro de produit/spécification
Prix
Qté
CA7-H52H4-100ug
$420.00
CA7-H52H4-1mg (500ug X 2)
$2940.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    Cadherin-17, CDH17, HPT-1, LI-cadherin

  • Source

    Human Cadherin-17 Protein, His Tag (Active) (CA7-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Met 787 (Accession # Q12864-1).

    Predicted N-terminus: Gln 23

    Request for sequence
  • Molecular Characterization

    Cadherin-17 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 86.9 kDa. The protein migrates as 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Cadherin-17 SDS-PAGE

    Human Cadherin-17 Protein, His Tag (Active) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Cadherin-17 ELISA

    Immobilized Human Cadherin-17 Protein, His Tag (Active) (Cat. No. CA7-H52H4) at 1 μg/mL (100 μL/well) can bind various dilution ratio of Anti-Cadherin 17/CDH17 Antibody (QC tested).

    Protocol

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Introduction de fond

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Cadherin-17

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    17 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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