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Human CD24 Protein, His Tag-Ferritin, low endotoxin

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Numéro de produit/spécification
Prix
Qté
CD4-H5246-100ug
$395.00
CD4-H5246-1mg
$2620.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    CD24, CD24A

  • Source

    Human CD24, His Tag-Ferritin (CD4-H5246) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Gly 59 | Ser 3 - Ser 167 (Accession # P25063-1&Q9ZLI1-1).

    Predicted N-terminus: His

    Request for sequence
  • Molecular Characterization

    CD24 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 24.2 kDa. The protein migrates as 32-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 100 mM NaCl, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    CD24 SDS-PAGE

    Human CD24, His Tag-Ferritin on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     CD24 ELISA

    Immobilized Human CD24, His Tag-Ferritin (Cat. No. CD4-H5246) at 5 μg/mL (100 μL/well) can bind Anti-CD24 MAb (SN3) with a linear range of 10-625 ng/mL (QC tested).

    Protocol

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Introduction de fond

CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Signal transducer CD24

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    7 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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