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Détails du produit
Synonyms
FLJ18683, T3E, TCRE, CD3E, CD3-epsilon
Source
Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag (CDE-C5253) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Thr 48 (Accession # Q95LI5 ).
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 29.3 kDa. The protein migrates as 33-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Affichage des données
SDS-PAGE
Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag (Cat. No. CDE-C5253) is more than 90% and the molecular weight of this protein is around 60-75 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Cynomolgus CD3 epsilon (22-48) Protein, Fc Tag (Cat. No. CDE-C5253) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2) (Cat. No. CDE-M531) with a linear range of 0.1-2 ng/mL (QC tested).
Protocol
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Introduction de fond
Its primary function is to act as a crucial structural scaffold, mediating proper interactions with other CD3 subunits (specifically CD3G and CD3D).
It is also considered as SP34 binding site.
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
T-cell surface glycoprotein CD3 epsilon chain
- Catégorie：
- Nombre de médicaments répertoriés：
4 Détails
- Nombre de médicaments cliniques：
7 Détails
- Étape de développement la plus élevée：
Approved
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