Mouse CD8 alpha / CD8A Protein, His Tag, low endotoxin

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Cat. No. / Size
Price
Qty
CDA-M52H9-100ug
$450.00
CDA-M52H9-1mg (500ug X 2)
$2980.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CD8A, CD8, Leu2, MAL, p32

  • Source

    Mouse CD8 alpha Protein, His Tag (CDA-M52H9) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Tyr 196 (Accession # P01731-1).

    Predicted N-terminus: Lys 28

    Request for sequence
  • Molecular Characterization

    CD8 alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 20.8 kDa. The protein migrates as 28-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD8 alpha SDS-PAGE

    Mouse CD8 alpha Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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Background

CD8 alpha is a critical surface protein on cytotoxic T cells. It acts as a co-receptor for the T-cell receptor (TCR), binding to MHC class I molecules to stabilize antigen recognition and enhance T-cell activation. It is predominantly expressed on the surface of cytotoxic T lymphocytes (CTLs) and a subset of natural killer (NK) cells. Anti-CD8 antibody are usually used to modify LNP in in vivo CAR, CD8 alpha protein could be used to detect anti-CD8 antibody density.

Recent Advances

 
Drug Development Progress
  • English Name:

    Cluster of differentiation 8

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    18 Details

  • Highest Development Stage:

    Phase 3 Clinical

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