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Détails du produit
Synonyms
CEACAM6, CD66c, CEAL, NCA
Source
Human CEACAM-6, Fc Tag (CE6-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 35 - Gly 320 (Accession # P40199-1).
Predicted N-terminus: Lys 35
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 57.7 kDa. The protein migrates as 75-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Affichage des données
SDS-PAGE
Human CEACAM-6, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-MALS
The purity of Human CEACAM-6, Fc Tag (Cat. No. CE6-H5254) is more than 95% and the molecular weight of this protein is around 165-195 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human CEACAM-8, His Tag (Cat. No. CE8-H5224) at 5 μg/mL (100 μL/well) can bind Human CEACAM-6, Fc Tag (Cat. No. CE6-H5254) with a linear range of 0.01-0.156 μg/mL (QC tested).
Protocol
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FAQ
- Product
Are there any studies showing that CEACAM6 and CEACAM8 can interact?
Yes. According to the reference “Diverse oligomeric states of CEACAM IgV domains” (PNAS), CEACAMs can form homophilic and/or heterophilic interactions (e.g., CEACAM6–CEACAM8, CEACAM5–CEACAM6). Structural studies of the CEACAM6–CEACAM8 heterodimer showed that the addition of CEACAM8 to CEACAM6 led to heterodimer formation, confirming their ability to bind each other.
Introduction de fond
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Carcinoembryonic antigen related cell adhesion molecule 6
- Catégorie：
- Nombre de médicaments répertoriés：
0 Détails
- Nombre de médicaments cliniques：
3 Détails
- Étape de développement la plus élevée：
Phase 2 Clinical
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