PE-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag (C-terminus) (Site-specific conjugation)

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Cat. No. / Size
Price
Qty
CLA-HP2H4-25tests
$360.00
CLA-HP2H4-200tests
$2245.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CLEC12A, MICL, CLL-1, CLL1, DCAL2, DCAL-2, CD371

  • Source

    PE-Labeled Human CLEC12A Protein, His Tag (C-terminus) (CLA-HP2H4) is produced via site-specific conjugation of PE to Human CLEC12A, His Tag under optimal conditions with a proprietary technology. Human CLEC12A Protein, His Tag (C-terminus) (CLA-HP2H4) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).

    Predicted N-terminus: His 65

    Request for sequence

  • Molecular Characterization

    CLEC12A Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 27.3 kDa.

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 0.5% BSA with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

     CLEC12A FACS

    5e5 of Anti-CLEC12A/CLL-1 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag (C-terminus) (Cat. No. CLA-HP2H4) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).​

    Protocol

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Background

CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

Recent Advances

 
Drug Development Progress
  • English Name:

    C-Type lectin domain family 12 member A

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    26 Details

  • Highest Development Stage:

    Phase 2 Clinical

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