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Mouse E-Selectin Protein, His Tag, low endotoxin (MALS verified)

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Numéro de produit/spécification
Prix
Qté
CDE-M52H3-100ug
$260.00
CDE-M52H3-1mg
$1750.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    SELE, RP1-117P20.2, CD62E, ELAM1, ESEL, LECAM2, E-Selectin

  • Source

    Mouse E-Selectin Protein, His Tag (CDE-M52H3) is expressed from human 293 cells (HEK293). It contains AA Trp 22 - Arg 556 (Accession # Q00690).

    Predicted N-terminus: Trp 22

    Request for sequence
  • Molecular Characterization

    E-Selectin Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 60.3 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    E-Selectin SDS-PAGE

    Mouse E-Selectin Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    E-Selectin SEC-MALS

    The purity of Mouse E-Selectin Protein, His Tag (Cat. No. CDE-M52H3) is more than 90% and the molecular weight of this protein is around 65-95 kDa verified by SEC-MALS.

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Introduction de fond

E-Selectin, a key member of the selectin family, is an adhesion molecule primarily expressed on vascular endothelial cells upon stimulation by pro-inflammatory cytokines like IL-1 and TNF-α. E-Selectin mediates the initial rolling of leukocytes on endothelium via recognizing sialyl Lewis X ligands, a critical step for leukocyte recruitment to inflamed tissues. It also participates in amplifying inflammatory responses and is implicated in pathological processes such as atherosclerosis and tumor metastasis. Its induced expression and ligand specificity make it a pivotal player in immune surveillance and inflammation.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Selectin E

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    4 Détails

  • Étape de développement la plus élevée:

    Phase 3 Clinical

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