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Human IFN-beta Protein, Fc Tag (MALS verified)

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Numéro de produit/spécification
Prix
Qté
IFB-H5254-100ug
$350.00
IFB-H5254-1mg (500ug X 2)
$2310.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    IFNB1, Interferon beta, IFN-beta, IFB, IFNB

  • Source

    Human IFN-beta Protein, Fc Tag (IFB-H5254) is expressed from human 293 cells (HEK293). It contains AA Met 22 - Asn 187 (Accession # P01574).

    Predicted N-terminus: Met 22

    Request for sequence
  • Molecular Characterization

    IFN-beta Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 46.5 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    IFN-beta SDS-PAGE

    Human IFN-beta Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IFN-beta SEC-MALS

    The purity of Human IFN-beta Protein, Fc Tag (Cat. No. IFB-H5254) is more than 85% and the molecular weight of this protein is around 95-120 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IFN-beta ELISA

    Immobilized Human IFNAR2, His Tag (Cat. No. IF2-H5224) at 5 μg/mL (100 μL/well) can bind Human IFN-beta Protein, Fc Tag (Cat. No. IFB-H5254) with a linear range of 0.03-2 ng/mL (QC tested).

    Protocol

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Introduction de fond

Interferon beta(IFN beta) is type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Interferon beta

  • Catégorie:

  • Nombre de médicaments répertoriés:

    1 Détails

  • Nombre de médicaments cliniques:

    6 Détails

  • Étape de développement la plus élevée:

    Approved

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