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Human IL-1 RAcP / IL-1 R3 Protein, His Tag, low endotoxin (MALS verified)

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Numéro de produit/spécification
Prix
Qté
ILP-H52H4-100ug
$215.00
ILP-H52H4-1mg (500ug X 2)
$1287.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    IL1RAP, IL-1RAcP, C3orf13, IL1R3

  • Source

    Human IL-1 RAcP Protein, His Tag (ILP-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Thr 367 (Accession # Q9NPH3-1).

    Predicted N-terminus: Ser 21

    Request for sequence
  • Molecular Characterization

    IL-1 RAcP Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 41.7 kDa. The protein migrates as 55-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    IL-1 RAcP SDS-PAGE

    Human IL-1 RAcP Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-1 RAcP SEC-MALS

    The purity of Human IL-1 RAcP Protein, His Tag (Cat. No. ILP-H52H4) is more than 90% and the molecular weight of this protein is around 45-70 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IL-1 RAcP ELISA

    Immobilized Human IL-1 RAcP Protein, His Tag (Cat. No. ILP-H52H4) at 1 μg/mL (100 μL/well) can bind Anti-IL-1 RAcP Antibody, Human IgG1 with a linear range of 0.06-1 ng/mL (QC tested).

    Protocol

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Introduction de fond

Interleukin-1 receptor accessory protein (IL1RAP or IL-1RAcP) is also known as Interleukin-1 receptor 3 (IL-1R-3 or IL-1R3), C3orf13, which belongs to the interleukin-1 receptor family. IL1RAP contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RAP is detected in liver, skin, placenta, thymus and lung. IL-1R3 / IL1RAP is coreceptor with IL1R1, associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Interleukin-1 receptor accessory protein

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    8 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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