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Human Mucin-1 / MUC-1 Protein, Llama IgG2b Fc Tag, low endotoxin

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Numéro de produit/spécification
Prix
Qté
MU1-H5255-100ug
$310.00
MU1-H5255-1mg (500ug X 2)
$2245.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    Mucin 1, MUC1, CD227, EMA, H23AG, KL-6, MAM6, MUC-1, SEC, MUC-1, X, MUC1, ZD, PEM, PEMT, PUM, CA15-3, Episialin

  • Source

    Human Mucin-1 Protein, Llama IgG2b Fc Tag (MU1-H5255) is expressed from human 293 cells (HEK293). It contains AA Ser 33 - Gly 167 (Accession # AAI20976).

    Predicted N-terminus: Ser 33

    Request for sequence
  • Molecular Characterization

    Mucin-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a llama IgG2b Fc tag at the C-terminus.

    The protein has a calculated MW of 42.4 kDa. The protein migrates as 50-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Mucin-1 SDS-PAGE

    Human Mucin-1 Protein, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

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Introduction de fond

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Mucin-1

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    28 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

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