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Détails du produit
Synonyms
PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Source
Canine PD-L1, Fc Tag (PD1-C52H3) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - His 238 (Accession # E2RKZ5-1).
Predicted N-terminus: Phe 19
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 51.4 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Affichage des données
SDS-PAGE
Canine PD-L1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
Bioactivity-BLI
Loaded Canine PD-1, His Tag (Cat. No. PD1-C52H9) on HIS1K Biosensor, can bind Canine PD-L1, Fc Tag (Cat. No. PD1-C52H3) with an affinity constant of 85 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
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Introduction de fond
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Programmed death-ligand 1
- Catégorie：
- Nombre de médicaments répertoriés：
12 Détails
- Nombre de médicaments cliniques：
176 Détails
- Étape de développement la plus élevée：
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